Genomic Feature
hu2526
- ID
- ZDB-ALT-070315-5
- Name
- hu2526
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Hubrecht Institute
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 68807513 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T at position 208 in GenBank:AF240772 in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Lys>Stop (1)
- Flanking Sequence
-
ATAATCAAAATCTACAAATAAAACCCTTTATTTTTTCTCATGGGAGCTGATTGACAAGCAAAAAAATAGCAGCTCAGGGATTGGGTTAGGTTAGACAGGGGGCGTGGCTTTGCCACCACGCGCCTGAACGCCTATAAAAACCGGTGCTGCGCATCAGACTTCACATTTCACATTTGTTAACGCACCTCGATGAAAGACCTCCACCTGCATACCTAACAGAAGAAAGCTTGGACATTTTCTGGAATCATATCCTCACTGATATCAACTATTGGAGTACACGTGCAATGAAAATCCTGGCACAGACTGAAAAAATCAAAATGGACAGAAAGGTAACAACTTGTTTCCAGATGAATACCATTGAGACATGCACATGCTGTAATATTAACCAGTTAAAACGTGATCTGTTGACTGACATTAGTCCTTTGCGTTTTCTGAAGCTGTTAAAACCTCAGGTAGAAAGACGTAGAAGAGAAAGGATGAACCGGAGTCTAGAAAACCTG
A/T AACTTCTGCTCCTGCAAGGCCCAGAACACAACGTAAGACCACCTTTTGCTTTTAAACACAGTGGCATCTATGAATATGTGACTAGCTTGATCCAAAGCTGATTTATGTCAACTCTTATGTTTTGTAGCAACCTAATCAGAGACGATTAGAGAAAGCAGAGATCCTGGAATACACAGTTCTGTTCCTGCAAAAGGCGAATAAAGCGAGTAAAGAAGAGGAGGGAGAAGAAAAAAGCCAGTTTATGGAAGGCTTTTCTTCCTGTCTTCAAAAAGCAGCCCGCTTTCTCTTGGAGGAAGGTGGACTGGAAGGCTCGGTCACATCCATGCTGTGTCAACGTCTTGCTCACCCCACCATCAGACTGCCTGTCAGAGGTCACTCCAGAAAGCAGCACGCAGAATCCAACCCACAGCATCATGCGCGTCGTCCACACCACAAAAACACTGTCTCCAAAGCAGGACATCCATCAGCTTGCAGGAACACCAAAGAACCACAAGCGAGCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| her7hu2526/hu2526 | Homozygous | ♀+/- ♂+/- | 4 figures  from 2 publications | 2 figures from Choorapoikayil et al., 2012 | |
| her7hu2526/hu2526 (AB) | Homozygous | ♀+/- ♂+/- | |||
| her7hu2526/+ (AB) | Heterozygous | Unknown | |||
| her7hu2526 | Unknown | Unknown | |||
| her7hu2526/hu2526; her1ci301/ci301 | Complex | ||||
| her7hu2526/hu2526; her1zf2173/zf2173 | Complex | 8 figures from 2 publications | 2 figures from LLeras Forero et al., 2018 | ||
| her7hu2526/hu2526; her1zf2173/zf2173; hu6867Tg | Complex | Fig. 5 from LLeras Forero et al., 2018 | |||
| her7hu2526/hu2526; her1zf2173/zf2173; hu7478Tg; nknkgsaizgffm1954AGt | Complex | Fig. S3 from Lleras-Forero et al., 2020 | |||
| her7hu2526/+; her1ci301/+ | Complex | ||||
| her7hu2526/hu2526; tbx6sa38869/sa38869; her1zf2173/zf2173 | Complex | 8 figures from 2 publications | 2 figures from LLeras Forero et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Keseroglu, K., Zinani, O.Q.H., Keskin, S., Seawall, H., Alpay, E.E., Özbudak, E.M. (2023) Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes. Nature communications. 14:64976497
- Naganathan, S.R., Popović, M., Oates, A.C. (2022) Left-right symmetry of zebrafish embryos requires somite surface tension. Nature. 605(7910):516-521
- Özelçi, E., Mailand, E., Rüegg, M., Oates, A.C., Sakar, M.S. (2022) Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation. Nature communications. 13:79347934
- Simsek, M.F., Chandel, A.S., Saparov, D., Zinani, O.Q.H., Clason, N., Özbudak, E.M. (2022) Periodic inhibition of Erk activity drives sequential somite segmentation. Nature. 613(7942):153-159
- Zinani, O.Q.H., Keseroğlu, K., Dey, S., Ay, A., Singh, A., Özbudak, E.M. (2022) Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes. iScience. 25:104579
- Lleras-Forero, L., Newham, E., Teufel, S., Kawakami, K., Hartmann, C., Hammond, C.L., Knight, R.D., Schulte-Merker, S. (2020) Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis. Aging. 12(18):18603-18621
- Zinani, O.Q.H., Keseroğlu, K., Ay, A., Özbudak, E.M. (2020) Pairing of segmentation clock genes drives robust pattern formation. Nature. 589(7842):431-436
- LLeras Forero, L., Narayanan, R., Huitema, L.F.A., VanBergen, M., Apschner, A., Peterson-Maduro, J., Logister, I., Valentin, G., Morelli, L.G., Oates, A., Schulte-Merker, S. (2018) Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock. eLIFE. 7
- Ay, A., Holland, J., Sperlea, A., Devakanmalai, G.S., Knierer, S., Sangervasi, S., Stevenson, A., Ozbudak, E.M. (2014) Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves. Development (Cambridge, England). 141:4158-67
- Ay, A., Knierer, S., Sperlea, A., Holland, J., and Ozbudak, E.M. (2013) Short-lived Her proteins drive robust synchronized oscillations in the zebrafish segmentation clock. Development (Cambridge, England). 140(15):3244-3253
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