Genomic Feature
hu2846
- ID
- ZDB-ALT-070315-12
- Name
- hu2846
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Hubrecht Institute
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 13: 25600535 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
TGAGATAAACACCAAGAGGAAAAACATTTTTAAAAGCACTAAAATTATGTTTAAAAATAAGCAAAAAACTGTTTTTGTACTCACTGTATTCATGAACAGTCCCACGGACATTTCCAAAAATAGCTTTCTCTTCCCTAAACTTGTGTTCAATAGCAAAATTATTTTTGATCCAGGAGTCATTTGTCATCAGGGTCCCCACCAGTTTATTTTGAACTTGGTTTGTGGGATAAACTGGTGTTGTGTCTCTGTCATATACAAACAGAGTCCCAAACACAGTACCCTACAAAAGAGAAAAGCTTATTAATATACAAGATCAAAAAAGCTAAGAAGATTACACACACACACACACACAAAATAGCACACACCTCACTGCGGTCAAACTCTACTAAGACGTCTTCAGTGTCAGTCCCGTTGACATAAGGAGAATTATCATCTTCATCATAGATGTTCACATGTAAAGATCTGAAGACCTCCTCCAGATTTCTTTCTGTTCGTACCAT
A/T CAGACTATATCCAGATGATACACTTCCTTCTCCTCGCGGTCCACTTGTGCTGTGACCACTAGTTCAGAAGTGGAGTCGTCGACCGCAAACGGTACAGAAGATCCTGAATTAAATATAAACAAGCACAGACAATCCATCTTAGAGTAGTGACGGGAGAAAATAAGTTTTCCAAATCTTTAAATGACTTAGACCAATTGCTTCATATAATGATTTTGAAGTGTTCAAATGATCACAGACTGAGTAACTCTGCTGGTCAAATCTGTGCAAATACAACAAAAACCCATGTCAAAAATGTATCAAAAACAGCTTTTACAAACACATTTAGCAAAGATTTATTGACTATAATTGATCAAATGCATTTAGCTAACCATCTAACATCATTAAATATACAACAAATCAGCATAATGTGCCTTCTTTTATCAATTTACAATACTTATTTTGTTTGTTGCATGGTGAGCTCTGCTAAACAGCCCAATGTGAAACTATTTTCTACCATTAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rethu2846/hu2846 | Homozygous | ♀+/- ♂+/- | 4 figures  from 3 publications | 3 figures from 2 publications | |
| rethu2846/+ | Heterozygous | ♀+/- ♂+/- | 3 figures from Heanue et al., 2016 | 2 figures from Heanue et al., 2016 | |
| rethu2846/+ (AB) | Heterozygous | Unknown | |||
| rethu2846 | Unknown | Unknown | |||
| rethu2846/hu2846; b1331Tg | Complex | Figure 7 from Bandla et al., 2022 | |||
| rethu2846/hu2846; nl1Tg | Complex | 6 figures from Tuttle et al., 2019 | 2 figures from Tuttle et al., 2019 | ||
| rethu2846/+; nksagff234aGt; nkuasgfp1aTg | Complex | Fig. 2 from Heanue et al., 2016 | Fig. S2 from Heanue et al., 2016 | ||
| mapk8ip3nl7/nl7; rethu2846/hu2846; nl1Tg | Complex | Figure 3 from Tuttle et al., 2019 | |||
| rethu2846/+; mapk10fci200/fci200 | Complex | Fig. 5 from Heanue et al., 2016 | |||
| rethu2846/+ + MO3-mapk10 | Complex | Fig. 4 from Heanue et al., 2016 |
1 - 10 of 11
Show
Supplemental Information
- Genotyping protocol
- None
- Bandla, A., Melancon, E., Taylor, C.R., Davidson, A.E., Eisen, J.S., Ganz, J. (2022) A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous System. International Journal of Molecular Sciences. 23(24):
- McCallum, S., Obata, Y., Fourli, E., Boeing, S., Peddie, C.J., Xu, Q., Horswell, S., Kelsh, R., Collinson, L., Wilkinson, D., Pin, C., Pachnis, V., Heanue, T.A. (2020) Enteric glia as a source of neural progenitors in adult zebrafish. eLIFE. 9:
- Wiles, T.J., Schlomann, B.H., Wall, E.S., Betancourt, R., Parthasarathy, R., Guillemin, K. (2020) Swimming motility of a gut bacterial symbiont promotes resistance to intestinal expulsion and enhances inflammation. PLoS Biology. 18:e3000661
- Tuttle, A., Drerup, C.M., Marra, M., McGraw, H., Nechiporuk, A.V. (2019) Retrograde Ret signaling controls sensory pioneer axon outgrowth. eLIFE. 8:
- Ganz, J., Baker, R.P., Hamilton, M.K., Melancon, E., Diba, P., Eisen, J.S., Parthasarathy, R. (2018) Image velocimetry and spectral analysis enable quantitative characterization of larval zebrafish gut motility. Neurogastroenterology and motility. 30(9):e13351
- Heanue, T.A., Boesmans, W., Bell, D.M., Kawakami, K., Vanden Berghe, P., Pachnis, V. (2016) A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity. PLoS Genetics. 12:e1006439
- Wiles, T.J., Jemielita, M., Baker, R.P., Schlomann, B.H., Logan, S.L., Ganz, J., Melancon, E., Eisen, J.S., Guillemin, K., Parthasarathy, R. (2016) Host Gut Motility Promotes Competitive Exclusion within a Model Intestinal Microbiota. PLoS Biology. 14:e1002517
- Knight, R.D., Mebus, K., d'Angelo, A., Yokoya, K., Heanue, T., and Roehl, H. (2011) Ret signalling integrates a craniofacial muscle module during development. Development (Cambridge, England). 138(10):2015-2024
1 - 8 of 8
Show