Genomic Feature
t24980
- ID
- ZDB-ALT-061212-2
- Name
- t24980
- Synonyms
-
- IT325TA (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 13: 15959020 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
-
Q360Stop
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 1166 in GenBank:AF092175 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 360 (1)
- Flanking Sequence
-
TGAGAACTCATAACGGTCCTGACTGCGGTACCCGCATAGGTTGCACTCAAAGGGGTCTCGGAAGCCATGACAGCCCATGTGGATGGTGTACATGACATGATCCAGGAACAAAACTCTGCAGTGGATACAGCGGTACGCCCTCAATTCTTCTCCATCTCCACTTAGCACCTTAAATCCTTCTGATGACGCTATACTCAAATCCATTCCTGCTGCTCGCAAAGCCTCAAACTGCCGGTGTTGTTCTTCCTTTACCCCTGGCAGGCCTCCATTTCTCATACCTGGAGCCATGTGGTTGGTCAGGTAGATGAGACCACCTGTGGCTGCTGTTCCGCTTACCCCGGCCGAACGCTCCTCGTTGTTGCTCTCAGTGTCAGTGGAATCCTGCCCGCTGGGACTGGGGGAACCGTCTTTGTCAACAGAGGCGGATTTGGACTTAGAGAGTAGGAGAAGGTGCTCTGCGGCGCTGTCTTTAGCAGAAACACCATTGCCTTCAGCTGTTT
G/A TGACTTGTGCAGGTTGTATAGAGGGCTGACCACCATGTCGGCGGACCCAGGAGAGGTCTGAACCAGAGGCCGCAAGGACTCTGCACCCAGATAGCTAATTGCACTGTTGATGGCCTGATCAATCACATGGGGCTGCATCAGCTCACCTGAGCCACTCTCGAAAGATAGCTCTGACAGACGATTCTCTCCTGAGGAAAAAATGTGAGAGAGCAAAGGATTTAACTAATTAATTTTGATTTAAAAAGGAATTTACCTATCACAAGAAAATGCATTTCTAATGCACTGTAAAACCCAATAAGTTCAGGTAACTCTAACCATTTGAGGAAACCGATTGCAACAAATCATTTAAGTTCAAAAACTAATCCTAATGAGTACTGTGAACTTAATCCATTTGAGTAAACAAAGCAATTTGAGCACAGTAAAGAGCAATAAATGACGAGATTCAAACCAACTCAAACCAACTGAGTGCTGTAAAACCCAATAAGTTAAGGGAACTCAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ikzf1t24980/t24980 | Homozygous | Unknown | |||
| ikzf1t24980/t24980 | Homozygous | ♀+/- ♂+/- | 2 figures  from 2 publications | 2 figures from 2 publications | |
| ikzf1t24980 | Unknown | Unknown | 2 figures from Schorpp et al., 2006 | ||
| ikzf1t24980/t24980; fr101Tg | Complex | Fig. 4 from Hess et al., 2012 | Fig. 4 from Hess et al., 2012 | ||
| ikzf1t24980/t24980; fr101Tg; fr103Tg/fr103Tg | Complex | 3 figures from Hess et al., 2012 | 2 figures from Hess et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Hess, I., Sagar, ., O Meara, C., Grün, D., Schorpp, M., Boehm, T. (2022) Stage-specific and cell type-specific requirements of ikzf1 during haematopoietic differentiation in zebrafish. Scientific Reports. 12:2140121401
- O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201
- Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270
- Hess, I., and Boehm, T. (2012) Intravital Imaging of Thymopoiesis Reveals Dynamic Lympho-Epithelial Interactions. Immunity. 36(2):298-309
- Paik, E.J., and Zon, L.I. (2010) Hematopoietic development in the zebrafish. The International journal of developmental biology. 54(6-7):1127-1137
- Schorpp, M., Bialecki, M., Diekhoff, D., Walderich, B., Odenthal, J., Maischein, H.M., Zapata, A.G., and Boehm, T. (2006) Conserved functions of ikaros in vertebrate lymphocyte development: genetic evidence for distinct larval and adult phases of T cell development and two lineages of B cells in zebrafish. Journal of immunology (Baltimore, Md. : 1950). 177(4):2463-2476
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