Genomic Feature
st49
- ID
- ZDB-ALT-061207-4
- Name
- st49
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Talbot Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 37447933 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Tyr>Stop at position 782 (1)
- Flanking Sequence
-
TATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATAACACATATAAGATCACCTCTGCTCATCAAAAAAAAAAAAAAATTGCTACAGTATTTTTCATTAATAATAGAAAAAAAGTTTCCATCTTCCAGACTTTTGAATGGTGTGTCATTAATTTGATTAACATATGTATCTAATTATATGTTCTTTACCCAAAAGCACAATTTTTTATACCGCTAACAAAAGTGATATCATCTGCCCACACTTACAAAAATGACAGATTTATACAAAACAAAAAGATTGAGGAATCATTTTACATGTGTCTTACTCAACCTAAAACACAAGTGGGTTTGTCTTGACACTGTTTAATTTCTTTTTAGGATCATCAAAACAATGGCTTGACGTTAAACAGCTATGTGGTGGCCAGCAGTGTTGGCAACTTCACCATCAAAAACCTGCAGGATCCTGTCAGGATAGAGATTGCACATTTGGAGTA
T/A CAGGTATTCATATTCTGTCAGTAAAGGTACAGATTCTTTATTTAGCTTGATGATTCCATGAGGATCACCAATAGAGCATCTTTTCATTCCACAAAATGTATTTTATAAAGAAAAATGTTCTTTAAAAATGTAAAGCATTTAAAAACTGTACAAAAAACCTGTTTGGTGTGTTCCGATACCTTTATTTTTCAGATTGTGCACAGTTCTATCAATATTAAATCATCTCTGTAGTAAGCTGTACTTAGTACAGCGAAATTAGTGCAATCATTAAAGTGCAAAAACAAAAATAAATAGGATAAAATATTGCTTCAATTATAGTGAGTTTTTATACGCATAAGAATATAATTACAAATTTGTACAAAATTAATGAAGTATTGATATAATACTACACAGTGATTGAATATGAAGAGAAAGTGTTAAATGCAGTATTGCACAAAATATGGATGTGTTAAAGTGTCAAGGTCTGTTAAAAAAATCACCTTTCAAAGTTTAAACTGAAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| adgrg6st49/st49 | Homozygous | ♀+/- ♂+/- | 12 figures  from 4 publications | 9 figures from 3 publications | |
| adgrg6st49/st49 | Homozygous | ♀-/- ♂+/- | Fig. 1 from Petersen et al., 2015 | ||
| adgrg6st49/st49 | Homozygous | Unknown | Fig. 6 from Fontenas et al., 2019 | ||
| adgrg6st49/+ | Heterozygous | Unknown | |||
| adgrg6st49/+ | Heterozygous | ♀+/- ♂+/- | 2 figures from Glenn et al., 2013 | 3 figures from Glenn et al., 2013 | |
| adgrg6st49/+ (AB) | Heterozygous | Unknown | |||
| adgrg6st49 | Unknown | Unknown | 3 figures from Pogoda et al., 2006 | ||
| adgrg6st49/st49; s1101tEt; st85Tg | Complex | Fig. 7 from Glenn et al., 2013 | Fig. 7 from Glenn et al., 2013 | ||
| adgrg6st49/st49; ue2Tg | Complex | Fig. 6 from Bradley et al., 2019 | |||
| adgrg6st49/st49; ue2Tg; vu19Tg | Complex | Fig. 6 from Fontenas et al., 2019 | Fig. 6 from Fontenas et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Bradley, E.C., Cunningham, R.L., Wilde, C., Morgan, R.K., Klug, E.A., Letcher, S.M., Schöneberg, T., Monk, K.R., Liebscher, I., Petersen, S.C. (2019) In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development. Annals of the New York Academy of Sciences. 1456(1):44-63
- Fontenas, L., Welsh, T.G., Piller, M., Coughenour, P., Gandhi, A.V., Prober, D.A., Kucenas, S. (2019) The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones. Cell Reports. 27:115-128.e5
- Sanchez, N.E., Harty, B.L., O'Reilly-Pol, T., Ackerman, S.D., Herbert, A.L., Holmgren, M., Johnson, S.L., Gray, R.S., Monk, K.R. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 7(10):3415-3425
- Küffer, A., Lakkaraju, A.K., Mogha, A., Petersen, S.C., Airich, K., Doucerain, C., Marpakwar, R., Bakirci, P., Senatore, A., Monnard, A., Schiavi, C., Nuvolone, M., Grosshans, B., Hornemann, S., Bassilana, F., Monk, K.R., Aguzzi, A. (2016) The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. 536(7617):464-8
- Petersen, S.C., Luo, R., Liebscher, I., Giera, S., Jeong, S.J., Mogha, A., Ghidinelli, M., Feltri, M.L., Schöneberg, T., Piao, X., Monk, K.R. (2015) The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron. 85:755-69
- Liebscher, I., Schön, J., Petersen, S.C., Fischer, L., Auerbach, N., Demberg, L.M., Mogha, A., Cöster, M., Simon, K., Rothemund, S., Monk, K.R., Schöneberg, T. (2014) A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133. Cell Reports. 9(6):2018-26
- Paavola, K.J., Sidik, H., Zuchero, J.B., Eckart, M., Talbot, W.S. (2014) Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126. Science signaling. 7:ra76
- Glenn, T.D., and Talbot, W.S. (2013) Analysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin. Development (Cambridge, England). 140(15):3167-75
- Patra, C., van Amerongen, M.J., Ghosh, S., Ricciardi, F., Sajjad, A., Novoyatleva, T., Mogha, A., Monk, K.R., Mühlfeld, C., and Engel, F.B. (2013) Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proceedings of the National Academy of Sciences of the United States of America. 110(42):16898-16903
- Monk, K.R., Naylor, S.G., Glenn, T.D., Mercurio, S., Perlin, J.R., Dominguez, C., Moens, C.B., and Talbot, W.S. (2009) A G protein-coupled receptor is essential for Schwann cells to initiate myelination. Science (New York, N.Y.). 325(5946):1402-1405
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