Gene
adgrg6
- ID
- ZDB-GENE-041014-357
- Name
- adhesion G protein-coupled receptor G6
- Symbol
- adgrg6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables G protein-coupled receptor activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ear development; and myelination. Acts upstream of or within several processes, including heart trabecula formation; myelination; and semicircular canal fusion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including head; otic vesicle; pericardial region; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1654 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 50 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns341 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| bns342 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| fr24 | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| sa25142 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| st49 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| st63 | Allele with one point mutation | Unknown | Missense | ENU | |
| st86 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| stl47 | Allele with one delins | Unknown | Frameshift | TALEN | |
| stl215 | Allele with one deletion | Unknown | Inframe Deletion | TALEN | |
| stl464 | Allele with one MNV | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lethal congenital contracture syndrome 9 | 616503 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | CUB domain | GAIN domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | GPS motif | Pentraxin-related | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:C6KFA3 | InterPro | 1185 | |||||||||
| UniProtKB:A0AB13A7J1 | InterPro | 1208 | |||||||||
| UniProtKB:A0AB32T6S1 | InterPro | 1293 | |||||||||
| UniProtKB:A0AB32T6U7 | InterPro | 1316 | |||||||||
| UniProtKB:A0AB32T828 | InterPro | 1251 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgrg6-201
(1)
|
Ensembl | 3,558 nt | ||
| mRNA |
adgrg6-202
(1)
|
Ensembl | 796 nt | ||
| mRNA |
adgrg6-203
(1)
|
Ensembl | 516 nt | ||
| mRNA |
adgrg6-204
(1)
|
Ensembl | 4,246 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202P1 | ZFIN Curated Data | |
| Encodes | EST | eu1654 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001163291 (1) | 4933 nt | ||
| Genomic | GenBank:BX004780 (2) | 188317 nt | ||
| Polypeptide | UniProtKB:A0AB32TDX5 (1) | 1727 aa |
- El-Hage, O., Mikdache, A., Boueid, M.J., Degerny, C., Tawk, M. (2025) Schwann cells have a limited window of time in which to initiate myelination signaling during early migration in vivo. Cells & development. 181:203993203993
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Cazorla-Vázquez, S., Kösters, P., Bertz, S., Pfister, F., Daniel, C., Dedden, M., Zundler, S., Jobst-Schwan, T., Amann, K., Engel, F.B. (2023) Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney. Cells. 12(15):
- Torregrosa-Carrión, R., Piñeiro-Sabarís, R., Siguero-Álvarez, M., Grego-Bessa, J., Luna-Zurita, L., Fernandes, V.S., MacGrogan, D., Stainier, D.Y.R., de la Pompa, J.L. (2021) Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Science advances. 7:eabj5445
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Leon, K., Cunningham, R.L., Riback, J.A., Feldman, E., Li, J., Sosnick, T.R., Zhao, M., Monk, K.R., Araç, D. (2020) Structural basis for adhesion G protein-coupled receptor Gpr126 function. Nature communications. 11:194
- Bradley, E.C., Cunningham, R.L., Wilde, C., Morgan, R.K., Klug, E.A., Letcher, S.M., Schöneberg, T., Monk, K.R., Liebscher, I., Petersen, S.C. (2019) In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development. Annals of the New York Academy of Sciences. 1456(1):44-63
- Diamantopoulou, E., Baxendale, S., de la Vega de León, A., Asad, A., Holdsworth, C.J., Abbas, L., Gillet, V.J., Wiggin, G.R., Whitfield, T.T. (2019) Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. eLIFE. 8:
- Ducommun Priest, M., Navarro, M.F., Bremer, J., Granato, M. (2019) Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. PLoS Genetics. 15:e1007982
- Fontenas, L., Welsh, T.G., Piller, M., Coughenour, P., Gandhi, A.V., Prober, D.A., Kucenas, S. (2019) The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones. Cell Reports. 27:115-128.e5
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