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ZIRC
ZFIN ID: ZDB-GENE-041014-357
Gene Name: adhesion G protein-coupled receptor G6
Gene Symbol: adgrg6    Nomenclature History

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Previous Names: bge, big ears (1), gpr126, lau, lauscher (1), si:ch211-202p1.3 (1), unm st49, unm_st49

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits G protein-coupled receptor activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including animal organ morphogenesis; cAMP-mediated signaling; and myelination. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Is expressed in several structures, including head; otic vesicle; pericardial region; pleuroperitoneal region; and sensory system. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6).
Genome Resources: Alliance (1),  Gene:561970 (1),  Ensembl(GRCz11):ENSDARG00000054137 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fr24 Point Mutation Unknown Premature Stop
sa25142 Point Mutation Unknown Splice Site ENU
st49 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st63 Point Mutation Unknown Missense ENU
    st86 Point Mutation Unknown Premature Stop ENU
    stl47 Indel Unknown Frameshift TALEN
    stl215 Small Deletion Unknown Inframe Deletion TALEN
    tb233c Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tk256a Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tr216e Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • vu39 Point Mutation Unknown Premature Stop
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-adgrg6 N/A 3
    MO2-adgrg6 N/A 2
    MO3-adgrg6 N/A 1
    MO4-adgrg6 N/A 1
    MO5-adgrg6 N/A 1
    MO6-adgrg6 N/A 1
    TALEN1-adgrg6 1
    TALEN2-adgrg6 1
    DISEASE ASSOCIATED WITH adgrg6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Lethal congenital contracture syndrome 9 616503
    DISEASE ASSOCIATED WITH adgrg6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cAMP-mediated signaling (more)
    Cellular Component integral component of membrane (more)
    Molecular Function collagen binding (more)
    GO Terms (all 26)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adgrg6-202 (1)    Ensembl 796
    adgrg6-203 (1)    Ensembl 516
    adgrg6-204 (1)    Ensembl 4246
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adgrg6 No data available
    MARKER RELATIONSHIPS
    adgrg6 Contained in: [BAC] CH211-202P1 (1) (order this)
    adgrg6 Encodes: [EST] eu1654 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001163291 (1) 3558 bp
    Genomic GenBank:BX004780 (1) 188317 bp
    Select Tool
    Polypeptide UniProtKB:F1Q7U5 (1) 1240 aa
    Sequence Clusters UniGene:76404 (1)
    Sequence Information (all 18)
    ORTHOLOGY for adgrg6 ( Chr: 20 )
    CITATIONS (45)