Genomic Feature
j1e60
- ID
- ZDB-ALT-060911-2
- Name
- j1e60
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stephen L. Johnson Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 22369137 (GRCz11) (1) Details
- Nucleotide change
- A/G
- Variant Notes
-
This mutation is a T to C transition.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C at position 436 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Cys>Arg at position 146 (1)
- Flanking Sequence
-
GTTGAAGTCAGATTTATTGACCATTACAATTTTTTTATATTTACAATATGTCTGATAATATTTTTCCTTCTGGAGTTACTCTTATTTGTTTTATTTTGGCTAGTAAAATAAATCAGTTATTAGAAATAAGTTATTAAAAATATAATGTTTAGAAATGTACTGAAAAAATATTCTCTCCGTTAAACAGAAATTGGTGAAAAAAAAAAACATGGGGGCTAATAATTCTGACTTCAACTGTATATATATATATATATATATATTTGTCTTTCTTAACTACACTTCAGACTAAATTGACAGCTCTAATATTCATGCATATCTCCATTTTTGTCTCTCACCAAGCCGAACAGTAAGTTGATATCTTCCTGATTTAACCGTAGCGGCATCCAAAGTTCCGACGCAGACGTAACATCCCTCAAATTCCTTCCTGACTTTTTCCACGGACACTCCTGTCTCAAGACTGGCTGAATATCGCAGACTGTTGGGAAGGGGCTGTCCGTCAC
A/G TTTCTGCAGGTTCAAGTTTTTCATATCTGGGTCTGTTGCCAAGCATGGGATCACCGTCGTATCTCCTTCTGCCGCAACAATGTCGAACACGATGGTCCTCCTGAAGGGATTTTCAGGATCTGCTGAGAGGAATGCTAAATCAAAAACCAATGAAACACAACCAAGGGGGCTTAGATCAAGACTTTACAGCTCAGAGAAAGAGAGAAAGTGAAAAACAACCCTCCATCATACCTAACAAACAAATACAAGCAACCCACACCAACAGTGTTTACACTTGGAAAAACAAATCTGCCAAGGACTGAGTTTAAGTGTTCGTTAAGTTGGATTATAAGAACATGCTTGAAAAATCACATGGCACAGAATGACATGCAGGTCATGCAGGTAACAAGTAAACAAAGAGGGCTGAAGGTTGGTATTTGAGGCATCTGTGGGTGTATATGGAATGATATAGGAAGATGAGAGATGCTTGAGCATGTGTTCGTAGGAGAAAGAAAGGGAGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| kitaj1e60/j1e60 | Homozygous | Unknown | Fig. for (j1e60) from Phenotype Annotation (1994-2006) | ||
| kitaj1e60/j1e60 | Homozygous | ♀+/- ♂+/- | 2 figures  from 2 publications | ||
| kitaj1e60/+ | Heterozygous | Unknown | |||
| kitaj1e60/+ (AB) | Heterozygous | Unknown | |||
| kitaj1e60/+ (SJA) | Heterozygous | Unknown | |||
| kitaj1e60/j1e60 + MO1-foxd3 | Complex | Fig. 5 from Cooper et al., 2009 |
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Supplemental Information
- Genotyping protocol
- None
- O'Reilly-Pol, T., and Johnson, S.L. (2013) Kit signaling is involved in melanocyte stem cell fate decisions in zebrafish embryos. Development (Cambridge, England). 140(5):996-1002
- Cooper, C.D., Linbo, T.H., and Raible, D.W. (2009) Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(4):875-886
- Rawls, J.F. and Johnson, S.L. (2003) Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival. Developmental Biology. 262(1):152-161
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