Genomic Feature
s403
- ID
- ZDB-ALT-060824-4
- Name
- s403
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 8: 27756007 (GRCz11) (1) Details
- Nucleotide change
- T/C
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C at position 454 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Ser>Pro (1)
- Flanking Sequence
-
TCTTTCACATTAGACAAAAATAATACACATTTTTTTAATCACACACTTTTAGTAGAATCACAAAACTGTAAAAAAAAAAAAAACATACATTCCTTGTAACTCTCATCATTTACACTTGGGTATTTTTCTTACATTCAGCAGCCTAAATAAAGGAATCAGCATGAGTGACATTAGTCCAAACATGCAGAACGCTTAGAAATAGTAGGTTAAGGGTAGAAAATATCTGTGGCAGTTCACTATCAGACGGCTAGCCTTCAAACAATTTATCCAAGCAGAGAATGGGCCACCCTGGAGGGATTAGGCCTGTACTAATATTTAAACCAAACACTCAGGGTCCAGTCTTACCCCTATAGCTGGGAAAAAATGTGAAGTTCTGTTGTGCGATTATATAAGATCCGAGGGTAAATTAAGCTAATTAAGAATCGAAATGTGTTTAATGTGGCTTCATGATTGTTGTTTTTTCAGGTAGTCGTGAGGCAGCGTTCGTATACGCGATCTCC
T/C CGGCTGGTGTGGTTTTCGCTATTACCCGCGCTTGCAGTCAAGGGGAGTTGAAGGCGTGCAACTGTGACCCACAGAAACGTGGACGAGCCAGTGACGAACGAGGAGAGTTTGACTGGGGAGGCTGTAGTGACAACATCAACTATGGGATAAAGTTCGCCAAAGCCTTCATAGATGCCAAAGAGCGAACTGTGAAAGACGCACGAGCGCTCATGAACCTTCATAACAACCGCTGTGGAAGAATGGTGAGAACGAAGGTTATATGACATATTAAAGTTGATTTAGGCCATGTCCACAAATAAATGAGTATTTTTATAAATGGTGTTTTCCTCACTTTTGTTTTTTTAAAAAAATCTCTGTCCACATGAAAATGCCAAAACGCACTGGGATGCGTGTTGAAGGCACACCCGACCAACAGGCGGCCGTAATGACACTTTTATACTGAAATGCGGAAATAAGTATTTGTATGAGTAAATTCTATAAAATCAAAGCAAACATGAGTA - Additional Sequence
- None
Fish
from 2 publications1 - 10 of 24
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Supplemental Information
- Genotyping protocol
- None
- Shi, W., Yi, X., Ruan, H., Wang, D., Wu, D., Jiang, P., Luo, L., Ma, X., Jiang, F., Li, C., Wu, W., Luo, L., Li, L., Wang, G., Qiu, J., Huang, H. (2025) An animal model recapitulates human hepatic diseases associated with GATA6 mutations. Proceedings of the National Academy of Sciences of the United States of America. 122:e2317801121e2317801121
- Choi, T.Y., Ninov, N., Stainier, D.Y., and Shin, D. (2014) Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes after Near Total Loss of Hepatocytes in Zebrafish. Gastroenterology. 146(3):776-88
- Shin, D., Weidinger, G., Moon, R.T., and Stainier, D.Y. (2012) Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver. Mechanisms of Development. 128(11-12):525-535
- Poulain, M., and Ober, E.A. (2011) Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Development (Cambridge, England). 138(16):3557-68
- Shin, D., Lee, Y., Poss, K.D., and Stainier, D.Y. (2011) Restriction of hepatic competence by Fgf signaling. Development (Cambridge, England). 138(7):1339-1348
- Curado, S., Ober, E.A., Walsh, S., Cortes-Hernandez, P., Verkade, H., Koehler, C.M., and Stainier, D.Y. (2010) The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. Disease models & mechanisms. 3(7-8):486-495
- Liu, J., and Stainier, D.Y. (2010) Tbx5 and Bmp Signaling Are Essential for Proepicardium Specification in Zebrafish. Circulation research. 106(12):1818-1828
- Ober, E.A., Verkade, H., Field, H.A., and Stainier, D.Y. (2006) Mesodermal Wnt2b signalling positively regulates liver specification. Nature. 442(7103):688-691
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