Genomic Feature
t25870
- ID
- ZDB-ALT-060823-2
- Name
- t25870
- Synonyms
-
- JD003FA (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 14: 23609835 (GRCz11) (1) Details
- Nucleotide change
- T/C
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
TATCACTTTTTAATTGTAATAATCATGTTATTACTGTATATTACCTATGTAATAGCAATTAAATTAGCCTAATGTCTTTGCAGTCTGTCTCATGTTTGTTGTGTAATGTGCTTGTAACTTCAGATGAGTCCAGACGATGATGCAGTGGTCACCCTGCTGTGTGAGTGGGCTGTTTCTTGTAAAAGGTCAGGGCCACATAGAGCCATGGTGGTGGCCAAACTCCTGGAGAAAAGGCAGACTGAGATTGAAGCAGAGGTGCTGCTAGCAATCATAAAGCACTACACAATATTTCAATATATCCAGCTGAACAGTTCATATTCACAGTAAAGAGAGTGTCTAAAAGTATACGTGTGTTCCTGTGTGTGTTTTTAGAGGTGCGGCGAGTCAGAAGTTGTAGATGAGAAAGGCTCTGTGTCCTCAGGGTCTCTGTCTGCTGCCACACTCCCTGTCTTTCAGGATGTCCTGCTGCAGTTTCTGGACACACAGGCCCCTGTGCTCAG
T/C GAGTTTATATGACATACCATAGGGCTGTTTTTTATTTATTTACAGTTATCTGCATTATTCCTATACCCCATGATACTTTACATGAATTATGGGCATAAATTTCATTAAACCCTAATCAGTCAGTGAACTTTTTATAGAAAATGGGATACAGTGAAGTGGCATTCTTTGTATGATATATTTTTCAGGATGCAATTTTAAAGTATATTAGGCTACTCAATTCAGCTAGACTCAATATTTTTAGTGATTAGTAGTTTATCATGTTGAATAAGGAGTTGACTAAATTGCAGGAAAAAGTATATTATTTGGACATTATTTTGTCCTCGAATCACATGCCTGATTACCAACTTCAAGTTTTCCACAACACTATTGCTGATGTATATTACTGTACTTCAGGGAATACAAAGAGTAAATAATCTGGATGAACAAAATGGTGAACTCATGATTTTATGATCATAGATATGCTTGTGGTGTAATCACGTTAAAATACCAGTTGTAATGTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| med12t25870/t25870 | Homozygous | Unknown | 4 figures  from Rau et al., 2006 | ||
| med12t25870/t25870 | Homozygous | ♀+/- ♂+/- | 2 figures from Segert et al., 2018 | 2 figures from Segert et al., 2018 | |
| med12gl10/+; med12t25870/+ | Complex | Fig. 2 from Keightley et al., 2011 | |||
| med12t25870/t25870; s896Tg | Complex | Fig. 1 from Segert et al., 2018 | Fig. 1 from Segert et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Segert, J., Schneider, I., Berger, I.M., Rottbauer, W., Just, S. (2018) Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish. Progress in Biophysics and Molecular Biology. 138:20-31
- Keightley, M.C., Layton, J.E., Hayman, J.W., Heath, J.K., and Lieschke, G.J. (2011) Mediator subunit 12 is required for neutrophil development in zebrafish. PLoS One. 6(8):e23845
- Rau, M.J., Fischer, S., and Neumann, C.J. (2006) Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development. Developmental Biology. 296(1):83-93
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