Genomic Feature
s459
- ID
- ZDB-ALT-050919-90
- Name
- s459
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 53578498 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 316 (1)
- Flanking Sequence
-
GGACAGAAGCGCCTCCTCACATCTTCTCCATCTCAGATAATGCTTATCAATACATGCTGACCGACCGGGAGAATCAGTCTGTGCTCATCACCGGAGAATCCGGCGCTGGGAAGACTGTAAACACTAAGAGGGTCATCCAGTATTTTGCTAGCATCGCTGCCGCTGGGGGATCCGCTGGAAAAAAGGACTCGAGCAAGGGAACGTTGGAGGATCAGATTATTCAAGCTAACCCTGCGCTGGAGGCTTTCGGCAATGCGAAAACGCTCCGAAACGACAACTCGTCTCGCTTCGGGAAATTCATCCGCATTCATTTCGGGACGAGCGGAAAACTGTCATCGGCTGATATCGAAACGTACCTGTTGGAGAAGTCAAGAGTGACCTTCCAGCTGAAGTCTGAGAGAAACTACCATATCTTCTTCCAGATATTATCCAACGAGAAGCCCGAGCTTCTGGACATGCTATTGATCACCAATAATCCATACGACTACTCGTACATCTCA
C/T AAGGAGAAGTGACCGTCTCATCTATCAATGATAATGAGGAGCTGATAGCGACCGATAAGGCTTTTGATGTGCTTGGCTTCACGTCTGAGGAGAAGATGGGAGTCTATAAGCTGACCGGCGCTATCATGCATTACGGAAACATGAAATTCAAGCAGAAGCAGCGCGAGGAGCAGGCCGAGCCCGACGGCACTGAAGACGCAGATAAAGCAGCTTATCTAATGGGGCTGAACTCTGCCGACCTGCTCAAAGGACTCTGCCATCCAAGGGTTAAGGTGGGCAATGAATATGTTACAAAAGGACAAAGTGTGGACCAGGTGTATTACTCAATCGGCGCACTGGCCAAGTCGGTGTATGAGAAAATGTTCAACTGGATGGTGGTGAGAATTAACCAATCCCTCGACACCAAGCAACATCGACAGTATTTCATCGGTGTGCTTGACATCGCTGGCTTTGAAATCTTTGATTTCAACACATTTGAACAACTCTGCATTAATTTCACC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| myh6s459/s459 | Homozygous | ♀+/- ♂+/- | 3 figures from Sarantis et al., 2019 | Fig. 6 from Sarantis et al., 2019 | |
| myh6s459 | Unknown | Unknown | Fig. for (s459) from Phenotype Annotation (1994-2006) | ||
| myh6s459/s459; s958Tg | Complex | 2 figures from Sarantis et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Sarantis, P., Gaitanaki, C., Beis, D. (2019) Ventricular remodeling of single-chambered myh6-/- adult zebrafish hearts occurs via a hyperplastic response and is accompanied by elastin deposition in the atrium. Cell and tissue research. 378(2):279-288
- Kalogirou, S., Malissovas, N., Moro, E., Argenton, F., Stainier, D.Y., Beis, D. (2014) Intracardiac Flow Dynamics Regulate Atrioventricular Valve Morphogenesis. Cardiovascular research. 104(1):49-60
- Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204
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