Genomic Feature
s457
- ID
- ZDB-ALT-050919-86
- Name
- s457
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 68878145 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Start Loss (1)
- Protein Consequence
- None
- Flanking Sequence
-
AAATCCGTTCAATAAAGTTACACACTAAGAGTTTTACAAAGAAACACTGTTATTTATACAGACTTTTAGATTATTATGATCAAATCCGTTCAATAAAGTTACACATAAGAGTTTTACAAAGAAACACTGTTATTTTACAGACTTTTAGATTATTATGATCAAATCCGTTCAATAAAGTTACACACTAAGAGTTTTACAAAGAAACACTGTTATTTTACAGACTTTTCCTATGGTTGAACTTTTGGGTGGGCCGAAATCAAAGGATGTGTGAGAGTGTCTGGCCTCGCGCGAATAAACGCCTGCACTGTTTCCAGCAGCAGTGAACTTGACAGCTCTGCTCTCTGATGTGCCTGACGGATCAGAGGGATTCCCGGGACACTGCAGGATGGCAGGGGTCATCAGGGGCCAGATGCACACTTTAAAAGCACTGCCCAAACCAGGACACCCTCAGACGAGACACGGTCGGACGCGAGAAAGAATCCAAACCTCTCCATTCGCAA
T/A GCAGCCGGTCATAGCGTGCGCTTCATTCGCGTTATTTGTTTTACGCGTTGTTGATTGCGTGTGGATCGATAAAAATGGCGCGTTTATTAAAGATCATCGCACAGCTTTCTTCGGTGCTTACTCCAGCCAGTTTTATCCAAGGTACCCGCTGTACATGATGCAGTTATACAGAGACTTCAGCGGGAATAAGATGCTGACTACTCCTGCTAGTGTTGACAACCCGGCTCTCCATCAGTCTGACTTCGTCCTGAGCTTGATTGCACAAGGTAAGCATGCACCTGATTGTTACTTTGCACCTTATGCAAAGTTGTTACATGATCCGGTAACACTTTACAATAATAGTACATGAATAATGATGTATTAATATAAGCAATACATTATAATAAATGAACGATATGTGTAAATCAAGCGCTAATCATGAACTAACTTTAATGAGTCTCAAGAGTCCTTGTGTGGATGAGGCTTCCTTGTAAACTTGTTAGGGCTATTACATGATTTTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| spaws457/s457 | Homozygous | ♀+/- ♂+/- | 4 figures from 2 publications | ||
| spaws457 | Unknown | Unknown | Fig. for (s457) from Phenotype Annotation (1994-2006) | ||
| spaws457/s457; f1Tg | Complex | Fig. 6 from Kalogirou et al., 2014 | |||
| spaws457/s457; f1Tg; ia5Tg | Complex | Fig. 5 from Kalogirou et al., 2014 | |||
| spaws457/s457; ia5Tg | Complex | Fig. 7 from Kalogirou et al., 2014 | Fig. 7 from Kalogirou et al., 2014 | ||
| spaws457/s457; ia5Tg; s849Tg | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Ferreira, R.R., Pakula, G., Klaeyle, L., Fukui, H., Vilfan, A., Supatto, W., Vermot, J. (2018) Chiral Cilia Orientation in the Left-Right Organizer. Cell Reports. 25:2008-2016.e4
- Kalogirou, S., Malissovas, N., Moro, E., Argenton, F., Stainier, D.Y., Beis, D. (2014) Intracardiac Flow Dynamics Regulate Atrioventricular Valve Morphogenesis. Cardiovascular research. 104(1):49-60
- Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204
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