Genomic Feature
tbfe2
- ID
- ZDB-ALT-050621-4
- Name
- tbfe2
- Synonyms
-
- tig453 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 33496308 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Tyr>Stop (1)
- Flanking Sequence
-
ACCAATCATAACCAAAAATAAAATAAAATAAAATAAAATAAAAAATAAATAAAAAATTAAATGAAATAAAATAAAGACAAAAACAATTACAGTAGGTTACCACAACCATAAATAAATTAATTACCAAATCATATTCAAAAATACCAAATCATATCCAATCATAAAATAAATAAAAAAAAATAATAATAAAATAAAATAAAATAAAGAGAAAAACAATTACGATAGGTAACCACAACCATAAATAAATTAATTACCAAATCATATACAAAAATACATAATCATATCCATATTTATTCACAAAACAAACAATCAAACAAAATAAATAAATAAAAATAAACACAACTAAATGAAATCAAATTTAATAAAACAAAATTCTCACCATTGTATCCATCTTGGTTGAGGTCTCCAAGTGGTGTAATGGAGCTCCCAAATCGGGCAAACATTTGTGTGCCGGTGAGGTGAGGTAGCTGAGGAATGAGATCCAGAGGACCTTTTTGCAT
A/T TACACATAAACTCGACCCAACTCCTCCAACCTCCCATCAGAGTCACGAACCATGAACATGGGAGCGCCAACCAGCAGGTCCATCATTCTGGAGGTGATGCAAACCACAAACTTAAACATTGAACACATTCTTGCGCGGTGCACATTCTTGTGATACCTGGTTTTGGTTACTTACCCGTCATTGTTAATGTCAGTGGCAGCCACAGAATAGCCGTAGTAAGACCCCATCTGAAAAAATAGGAAAAAAATGTAAATATTACAATGGAGTTTAATTATGAAGAATTATTCAGAAATGATAGTTAAAATTGGATGGAATTCGAGTAGTGCTTTTAGAACAATGGTTTAATAAAATAATCAAAACCATTTCACAAAAATCCTGAGAACTGCAATAATTGTAGCATTAAAAACATTCACAGATGAACTTTCTGAGGAGACATCCTCAGGCATCACTAGTCTCACACACTGCTCTGTTCCCATAAAGAACTCTGATTATATATGCAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| itga5tbfe2/tbfe2 | Homozygous | Unknown | Fig. for (tbfe2) from Phenotype Annotation (1994-2006) | ||
| itga5tbfe2/tbfe2 | Homozygous | ♀+/- ♂+/- | Fig. 1  from Lackner et al., 2013 | ||
| itga5tbfe2/tbfe2 + MO2-efnb2a | Complex | Fig. 5 from Lackner et al., 2013 | |||
| itga5tbfe2/tbfe2 + MO1-rap1b | Complex | Fig. 1 from Lackner et al., 2013 | Fig. 3 from Lackner et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- Dray, N., Lawton, A., Nandi, A., Jülich, D., Emonet, T., and Holley, S.A. (2013) Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics. Current biology : CB. 23(14):1335-41
- Lackner, S., Schwendinger-Schreck, J., Jülich, D., and Holley, S.A. (2013) Segmental assembly of fibronectin matrix requires rap1b and integrin alpha5. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(2):122-131
- Jülich, D., Mould, A.P., Koper, E., and Holley, S.A. (2009) Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling. Development (Cambridge, England). 136(17):2913-2921
- Mara, A., Schroeder, J., Chalouni, C., and Holley, S.A. (2007) Priming, initiation and synchronization of the segmentation clock by deltaD and deltaC. Nature cell biology. 9(5):523-530
- Jülich, D., Geisler, R., Tübingen 2000 Screen Consortium, and Holley, S.A. (2005) Integrinalpha5 and Delta/Notch Signaling Have Complementary Spatiotemporal Requirements during Zebrafish Somitogenesis. Developmental Cell. 8(4):575-586
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