Genomic Feature
rw716
- ID
- ZDB-ALT-050324-2
- Name
- rw716
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- sperm treated with ENU
- Lab of Origin
- Okamoto Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 12: 8956639 (GRCz11) (1) Details
- Nucleotide change
- C/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>T at position 814 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Glu>Stop at position 272 (1)
- Flanking Sequence
-
GAAGTTCAACTTACATTCAATTCAAAGGTTTTGAGTGCGACTCTGAATCCTCCAGGAACAGGAGGGTTGATTCTGAGAGTTTCTTTAATCACACATCCAGTGTACTTCAGCTGGTCCAACAGCTCCATGCTCAAGCCTTTTCCCGGTGTATACATGCCCATTTCAACCTGTCAATGCAAATTTAACATTAGCCCTGGCCCTGATTGAGTAACATCATCAAACTCAGAATGAAACTTCTTAGATCTTACCTTCTCCTGAACCTCCTCTCTGACCTTCTGCACCACTTCTGTGTTCAGACCCAGAAACATGACTAGTGAGGTTGCAGTACTGGCGGTGGTTTCATGACCTCCAAATAGAAGCTCTGTAGCTGCTTCTTTCATCGCCTAAGCAATACGAAACATCACATTAGCACTGAATCGTACTTTTTGTGGGGCACAGAATAATATAAAAATAATACACTACCTGCAAACTAAAAGGTTCGTCACTTCTTCTGCTGTTCT
C/A GATCAACAGCTGAAGAGCGTCTTTGTATTTCTGCTCGTTTTCATTGTCGTCATCTTGAATTTTCTTCCTGATGTTTTCCTCAATTTTAGAGTGAATGAAATTGCGTGCCCTCAAACCCTGCCGATCAAAAATCACACAAGTTGAGTTTAAGAGTATCGCATATTGAGAATGCATCTTCAGACATTTGTTCTGAGTAACTCACCCTGTACAGACCACTGAAAGGAACGTCGATTGGCAAGGAGAACAAGTTTTTGATCATTTCCTCAAAAGCTTCCACCAGTTCTTGCTCGTCCGTCTTTATTTGCTCTGGTTCAAAACCAAGCAGGATTCTCATAGCTATCCGAAACATGAGTTTCTTCATTTCTGGATAAACCAGCACGCAGGAGTCTTTTTGCAGCCATTCCTGTATGGCGCTCTTCACCTCCTGCTGGATCACGGGAATGTAGTGCTCCAGAGCATCTCGAGAGAACGCCCTCATAATGGCCTAAAACAGAAGAAGA - Additional Sequence
- None
Fish
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Supplemental Information
- Genotyping protocol
- None
- Isabella, A.J., Barsh, G.R., Stonick, J.A., Dubrulle, J., Moens, C.B. (2020) Retinoic Acid Organizes the Zebrafish Vagus Motor Topographic Map via Spatiotemporal Coordination of Hgf/Met Signaling. Developmental Cell. 53(3):344-357.e5
- Song, Y.C., Dohn, T.E., Rydeen, A.B., Nechiporuk, A.V., Waxman, J.S. (2019) HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development. PLoS Genetics. 15:e1008165
- Chang, J., Skromne, I., Ho, R.K. (2016) CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition. Developmental Biology. 410(2):178-89
- Rydeen, A.B., Waxman, J.S. (2016) Cyp26 Enzymes Facilitate Second Heart Field Progenitor Addition and Maintenance of Ventricular Integrity. PLoS Biology. 14:e2000504
- Rydeen, A., Voisin, N., D'Aniello, E., Ravisankar, P., Devignes, C.S., Waxman, J.S. (2015) Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling. Developmental Biology. 405(1):47-55
- Rydeen, A.B., Waxman, J.S. (2014) Cyp26 enzymes are required to balance the cardiac and vascular lineages within the anterior lateral plate mesoderm. Development (Cambridge, England). 141:1638-48
- Drummond, D.L., Cheng, C.S., Selland, L.G., Hocking, J.C., Prichard, L.B., and Waskiewicz, A.J. (2013) The role of Zic transcription factors in regulating hindbrain retinoic acid signaling. BMC Developmental Biology. 13:31
- He, X., Yan, Y.L., Eberhart, J.K., Herpin, A., Wagner, T.U., Schartl, M., and Postlethwait, J.H. (2011) miR-196 regulates axial patterning and pectoral appendage initiation. Developmental Biology. 357(2):463-77
- Feng, L., Hernandez, R.E., Waxman, J.S., Yelon, D., and Moens, C.B. (2010) Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Developmental Biology. 338(1):1-14
- Martin, B.L., and Kimelman, D. (2010) Brachyury establishes the embryonic mesodermal progenitor niche. Genes & Development. 24(24):2778-2783
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