Genomic Feature
fw039k
- ID
- ZDB-ALT-041104-2
- Name
- fw039k
- Synonyms
-
- fw039-k (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- The Fishman Laboratory
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 30764574 (GRCz11) (1) Details
- Nucleotide change
- T/G
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>G in Intron 7 (1)
- Transcript Consequence
- Cryptic Acceptor Splice Site (1)
- Protein Consequence
- Amino Acid Insertion: 3 AA added (1)
- Flanking Sequence
-
TAGAGGCTTGGAATGTCCTTAAGTAAACCCTGTTGGTTGTGAATGAGTTTATCTCCTTTCTGTGATTGTGTTAAGGGTGCAAAAGTTGGTAAACTCACTCTGAAGACGACAGAGATGGAAACCATATATGATCTGGGGACTAAGATGATCGAGAGCCTCAGTAAAGAGAGAGTACAAGCCGGGTAGGTGGATTTTAAAGCTGAAATCTGTGGTCATTTTCTATTTATAACAAATTCGCCAGACTGGGCTGCACAATAGCAGTGTTAATAATTATAGTGATCGTTTGAAAATGATGATGATTACTTTTATTTATTGCTAGGTTGATAAATGATTAAATATGCTTTGAACAGTGTGTTTACTTTGGCAAGACTTATACAATATAATTCTCATTTATTATATGAATAAACAACAAAACTAAACTTTTGAGGTCTGAGCCAAACCTCATTATTCAGGCTTTCATGTGCTTAAATTGTTAAATGACCTCATAATGTCATATTTCA
T/G TTTCTGCAGAGATGTGATTACTATTGATAAAGCCACAGGGAAGATTAGCAAGCTTGGACGGTCATTTACTCGAGCAAGAGACTATGATGCCATGGGAGCACAGGTACACAGTTTGTCTTCATCTGTGAAATGAATCCATCAATCAATGCCACCAGTTCCCAGAGAGAGTTTTTTATATATGTTTATTGTGTTTAATGTTTATTTCAGACGCAGTTTGTGCAGTGTCCAGAGGGGGAACTTCAAAAAAGGAAGGAGGTTGTTCACACCGTCTCTCTTCATGAAATTGACGTCATCAACAGCCGCACACAGGGATTCTTGGCCTTATTTTCAGGTTTGCCATGCTCTTGTAATTGTTTTTATACTGCTCTTTGAGTGGTGTTTTTTAATAATATCTGTTCATAGATGTTTGAGTATGCGCTGTGTTGTTTGATGGTCTGTTCTGCAGGCGACACAGGAGAGATTAAGTCAGAGGTTCGGGAGCAGATCAATGCTAAAGTGTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ruvbl2fw039k/fw039k | Homozygous | Unknown | Fig. for (fw039-k) from Phenotype Annotation (1994-2006) | ||
| ruvbl2fw039k/fw039k | Homozygous | ♀+/- ♂+/- | 4 figures from Rottbauer et al., 2002 | 3 figures from Rottbauer et al., 2002 | |
| ruvbl2fw039k/+ | Heterozygous | ♀+/- ♂+/- | Fig. 5 from Rottbauer et al., 2002 | Fig. 5 from Rottbauer et al., 2002 | |
| ruvbl2fw039k/fw039k + MO1-ctnnb1 | Complex | Fig. 7 from Rottbauer et al., 2002 | Fig. 7 from Rottbauer et al., 2002 | ||
| ruvbl2fw039k/+ + MO1-ctnnb1 | Complex | Fig. 7 from Rottbauer et al., 2002 | Fig. 7 from Rottbauer et al., 2002 | ||
| ruvbl2fw039k/+ + MO1-ruvbl1 | Complex | text only from Rottbauer et al., 2002 | |||
| ruvbl2fw039k/+ + MO2-ruvbl1 | Complex | text only from Rottbauer et al., 2002 |
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Supplemental Information
- Genotyping protocol
- None
- Sharpe, M., González-Rosa, J.M., Wranitz, F., Jeffrey, S., Copenhaver, K., Burns, C.G., Burns, C.E. (2022) Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration. Frontiers in cell and developmental biology. 10:800594
- Rottbauer, W., Saurin, A.J., Lickert, H., Shen, X., Burns, C.G., Wo, Z.G., Kemler, R., Kingston, R., Wu, C., and Fishman, M. (2002) Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell. 111(5):661-672
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