PUBLICATION

Reptin and pontin antagonistically regulate heart growth in zebrafish embryos

Authors
Rottbauer, W., Saurin, A.J., Lickert, H., Shen, X., Burns, C.G., Wo, Z.G., Kemler, R., Kingston, R., Wu, C., and Fishman, M.
ID
ZDB-PUB-021204-1
Date
2002
Source
Cell   111(5): 661-672 (Journal)
Registered Authors
Fishman, Mark C., Rottbauer, Wolfgang
Keywords
none
MeSH Terms
  • Carrier Proteins
  • Embryo, Nonmammalian
  • Myocardium/cytology
  • Myocardium/ultrastructure
  • ATP-Dependent Proteases
  • Base Sequence
  • Amino Acid Sequence
  • Nuclear Proteins/genetics
  • Nuclear Proteins/physiology*
  • Sequence Homology, Amino Acid
  • Cardiomegaly/embryology
  • Cardiomegaly/etiology
  • Cardiomegaly/genetics
  • Gene Expression Regulation, Developmental
  • Serine Endopeptidases/physiology
  • Heart/embryology*
  • Heat-Shock Proteins/physiology
  • Trans-Activators/physiology
  • Conserved Sequence
  • Zebrafish
  • Point Mutation
  • Adenosine Triphosphatases/chemistry
  • Adenosine Triphosphatases/physiology
  • Cytoskeletal Proteins/physiology
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology*
  • Molecular Sequence Data
  • beta Catenin
  • Animals
  • Cell Division
  • Enzyme Activation
(all 32)
PubMed
12464178 Full text @ Cell
Abstract
Organ size is precisely regulated during development, but the control mechanisms remain obscure. We have isolated a mutation in zebrafish, liebeskummer (lik), which causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. The mutation activates ATPase activity of Reptin complexes and causes a cell-autonomous proliferation of cardiomyocytes to begin well after progenitors have fashioned the primitive heart tube. With regard to heart growth, beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. Pontin reduction phenocopies the cardiac hyperplasia of the lik mutation. Thus, the Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway.
Genes / Markers
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Rottbauer, W., Saurin, A.J., Lickert, H., Shen, X., Burns, C.G., Wo, Z.G., Kemler, R., Kingston, R., Wu, C., and Fishman, M. (2002) Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell. 111(5):661-672.