Genomic Feature
hi2217Tg
- ID
- ZDB-ALT-040924-4
- Name
- hi2217Tg
- Synonyms
-
- hi2217 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 17: 2039000 - 2039001 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| spint1ahi2217Tg/hi2217Tg | Homozygous | Unknown | 10 figures  from 5 publications | 6 figures from 2 publications | |
| spint1ahi2217Tg/hi2217Tg | Homozygous | ♀+/- ♂+/- | 7 figures from 3 publications | 2 figures from Armistead et al., 2020 | |
| spint1ahi2217Tg/hi2217Tg (AB) | Homozygous | ♀+/- ♂+/- | 5 figures from Mathias et al., 2007 | 5 figures from Mathias et al., 2007 | |
| spint1ahi2217Tg/+ (AB) | Heterozygous | Unknown | |||
| spint1ahi2217Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| spint1ahi2217Tg | Unknown | Unknown | Fig. for (hi2217) from Phenotype Annotation (1994-2006) | ||
| spint1ahi2217Tg/hi2217Tg; c264Tg; sh267Tg | Complex | Fig. 7 from Tyrkalska et al., 2019 | |||
| spint1ahi2217Tg/hi2217Tg; cy22Tg | Complex | Fig. 3 from Schepis et al., 2018 | |||
| spint1ahi2217Tg/hi2217Tg; fr46Tg; gz7Tg | Complex | Fig. 3 from Armistead et al., 2020 | Fig. 3 from Armistead et al., 2020 | ||
| spint1ahi2217Tg/hi2217Tg; hzm1Et | Complex | Fig. 3 from Gómez-Abenza et al., 2019 | Fig. 3 from Gómez-Abenza et al., 2019 |
1 - 10 of 38
Show
Supplemental Information
- Genotyping protocol
- None
- Armistead, J., Höpfl, S., Goldhausen, P., Müller-Hartmann, A., Fahle, E., Hatzold, J., Franzen, R., Brodesser, S., Radde, N.E., Hammerschmidt, M. (2024) A sphingolipid rheostat controls apoptosis versus apical cell extrusion as alternative tumour-suppressive mechanisms. Cell Death & Disease. 15:746746
- Arroyo, A.B., Tyrkalska, S.D., Bastida-Martínez, E., Monera-Girona, A.J., Cantón-Sandoval, J., Bernal-Carrión, M., García-Moreno, D., Elías-Arnanz, M., Mulero, V. (2024) Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation. Cell death discovery. 10:388388
- Hatzold, J., Nett, V., Brantsch, S., Zhang, J.L., Armistead, J., Wessendorf, H., Stephens, R., Humbert, P.O., Iden, S., Hammerschmidt, M. (2023) Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLoS Genetics. 19:e1010873e1010873
- Rodríguez-Ruiz, L., Lozano-Gil, J.M., Naranjo-Sánchez, E., Martínez-Balsalobre, E., Martínez-López, A., Lachaud, C., Blanquer, M., Phung, T.K., García-Moreno, D., Cayuela, M.L., Tyrkalska, S.D., Pérez-Oliva, A.B., Mulero, V. (2023) ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome. EMBO Molecular Medicine. 15(10):e18142
- Fatás-Lalana, B., Cantón-Sandoval, J., Rodríguez-Ruiz, L., Corbalán-Vélez, R., Martínez-Menchón, T., Pérez-Oliva, A.B., Mulero, V. (2022) Impact of Comorbidities of Patients with Psoriasis on Phototherapy Responses. International Journal of Molecular Sciences. 23(17)
- Hernández-Silva, D., Cantón-Sandoval, J., Martínez-Navarro, F.J., Pérez-Sánchez, H., de Oliveira, S., Mulero, V., Alcaraz-Pérez, F., Cayuela, M.L. (2022) Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation. International Journal of Molecular Sciences. 23(18)
- Ma, J., Scott, C.A., Ho, Y.N., Mahabaleshwar, H., Marsay, K.S., Zhang, C., Teow, C.K., Ng, S.S., Zhang, W., Tergaonkar, V., Partridge, L.J., Roy, S., Amaya, E., Carney, T.J. (2021) Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX. eLIFE. 10:
- Martínez-Morcillo, F.J., Cantón-Sandoval, J., Martínez-Navarro, F.J., Cabas, I., Martínez-Vicente, I., Armistead, J., Hatzold, J., López-Muñoz, A., Martínez-Menchón, T., Corbalán-Vélez, R., Lacal, J., Hammerschmidt, M., García-Borrón, J.C., García-Ayala, A., Cayuela, M.L., Pérez-Oliva, A.B., García-Moreno, D., Mulero, V. (2021) NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. PLoS Biology. 19:e3001455
- Armistead, J., Hatzold, J., van Roye, A., Fahle, E., Hammerschmidt, M. (2020) Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase. The Journal of cell biology. 219(2):
- Martínez-Navarro, F.J., Martínez-Morcillo, F.J., López-Muñoz, A., Pardo-Sánchez, I., Martínez-Menchón, T., Corbalán-Vélez, R., Cayuela, M.L., Pérez-Oliva, A.B., García-Moreno, D., Mulero, V. (2020) The vitamin B6-dependent enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation. Developmental and comparative immunology. 108:103666
1 - 10 of 18
Show