Genomic Feature
hi3020Tg
- ID
- ZDB-ALT-040712-6
- Name
- hi3020Tg
- Synonyms
-
- hi3020 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 22: 4438868 - 4438869 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| uhrf1hi3020Tg/hi3020Tg | Homozygous | Unknown | Fig. S6 from Sadler et al., 2007 | ||
| uhrf1hi3020Tg/hi3020Tg | Homozygous | ♀+/- ♂+/- | 4 figures  from Tittle et al., 2011 | 3 figures from Tittle et al., 2011 | |
| uhrf1hi3020Tg | Unknown | Unknown | Fig. for (hi3020) from Phenotype Annotation (1994-2006) | ||
| uhrf1pd1092/+; uhrf1hi3020Tg/+ | Complex | ||||
| dnmt1s872/s872; uhrf1hi3020Tg/hi3020Tg | Complex | 2 figures from Tittle et al., 2011 | |||
| dnmt1s872/+; uhrf1hi3020Tg/+ | Complex | Fig. 4 from Tittle et al., 2011 |
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Supplemental Information
- Genotyping protocol
- None
- Marjoram, L., Alvers, A., Deerhake, M.E., Bagwell, J., Mankiewicz, J., Cocchiaro, J.L., Beerman, R.W., Willer, J., Sumigray, K.D., Katsanis, N., Tobin, D.M., Rawls, J.F., Goll, M.G., Bagnat, M. (2015) Epigenetic control of intestinal barrier function and inflammation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(9):2770-5
- Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M. (2011) Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens. Developmental Biology. 350(1):50-63
- Sadler, K.C., Krahn, K.N., Gaur, N.A., and Ukomadu, C. (2007) Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1. Proceedings of the National Academy of Sciences of the United States of America. 104(5):1570-1575
- Gross, J.M., Perkins, B.D., Amsterdam, A., Egana, A., Darland, T., Matsui, J.I., Sciascia, S., Hopkins, N., and Dowling, J.E. (2005) Identification of Zebrafish Insertional Mutants with Defects in Visual System Development and Function. Genetics. 170(1):245-261
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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