Genomic Feature
hi272Tg
- ID
- ZDB-ALT-040712-4
- Name
- hi272Tg
- Synonyms
-
- hi272 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 22: 4438896 - 4438897 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| uhrf1hi272Tg/hi272Tg | Homozygous | Unknown | 3 figures from 2 publications | Fig. S6 from Sadler et al., 2007 | |
| uhrf1hi272Tg/hi272Tg | Homozygous | ♀+/- ♂+/- | Fig. 5  from Feng et al., 2010 | 4 figures from Chernyavskaya et al., 2017 | |
| uhrf1hi272Tg/+ (AB) | Heterozygous | Unknown | |||
| uhrf1hi272Tg/+ (AB/TU) | Heterozygous | Unknown | 2 figures from Sadler et al., 2007 | ||
| uhrf1hi272Tg | Unknown | Unknown | 6 figures from 2 publications | ||
| uhrf1b1115/+; uhrf1hi272Tg/+ | Complex | Fig. 1 from Ganz et al., 2019 | |||
| uhrf1hi272Tg/hi272Tg; c269Tg | Complex | Fig. 5 from Feng et al., 2010 | |||
| uhrf1hi272Tg/hi272Tg; gl23Tg | Complex | Fig. 4 from Chernyavskaya et al., 2017 | 2 figures from Chernyavskaya et al., 2017 | ||
| uhrf1hi272Tg/hi272Tg; mss4Tg | Complex | 2 figures from Madakashira et al., 2021 | |||
| uhrf1hi272Tg/hi272Tg; mss8Tg | Complex | Figure 6 from Madakashira et al., 2021 |
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Supplemental Information
- Genotyping protocol
- hi272tg.pdf
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
- Madakashira, B.P., Zhang, C., Macchi, F., Magnani, E., Sadler, K.C. (2021) Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Genes. 12(7):
- Magnani, E., Macchi, F., Madakashira, B.P., Zhang, C., Alaydaroos, F., Sadler, K.C. (2021) uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements. Frontiers in immunology. 12:627926
- Ganz, J., Melancon, E., Wilson, C., Amores, A., Batzel, P., Strader, M., Braasch, I., Diba, P., Kuhlman, J.A., Postlethwait, J.H., Eisen, J.S. (2019) Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development. Developmental Biology. 455:473-484
- Chernyavskaya, Y., Mudbhary, R., Tokarz, D., Jacob, V., Gopinath, S., Zhang, C., Sun, X., Wang, S., Magnani, E., Madakashira, B.P., Yoder, J.A., Hoshida, Y., Sadler, K.C. (2017) Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Development (Cambridge, England). 144(16):2925-2939
- Jacob, V., Chernyavskaya, Y., Chen, X., Tan, P.S., Kent, B., Hoshida, Y., Sadler, K.C. (2015) DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development (Cambridge, England). 142(3):510-21
- Feng, S., Cokus, S.J., Zhang, X., Chen, P.Y., Bostick, M., Goll, M.G., Hetzel, J., Jain, J., Strauss, S.H., Halpern, M.E., Ukomadu, C., Sadler, K.C., Pradhan, S., Pellegrini, M., and Jacobsen, S.E. (2010) Conservation and divergence of methylation patterning in plants and animals. Proceedings of the National Academy of Sciences of the United States of America. 107(19):8689-8694
- Sadler, K.C., Krahn, K.N., Gaur, N.A., and Ukomadu, C. (2007) Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1. Proceedings of the National Academy of Sciences of the United States of America. 104(5):1570-1575
- Gross, J.M., Perkins, B.D., Amsterdam, A., Egana, A., Darland, T., Matsui, J.I., Sciascia, S., Hopkins, N., and Dowling, J.E. (2005) Identification of Zebrafish Insertional Mutants with Defects in Visual System Development and Function. Genetics. 170(1):245-261
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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