Genomic Feature
hi2903Tg
- ID
- ZDB-ALT-040622-14
- Name
- hi2903Tg
- Synonyms
-
- hi2903 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion
- Protocol
- DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 20: 54079640 - 54079641 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rps29hi2903Tg/hi2903Tg | Homozygous | ♀+/- ♂+/- | 7 figures from 5 publications | 7 figures from 3 publications | |
| rps29hi2903Tg/+ | Heterozygous | Unknown | Fig. 2  from Zhang et al., 2010 | 2 figures from Taylor et al., 2012 | |
| rps29hi2903Tg/+ | Heterozygous | ♀+/- ♂+/- | Fig. 1 from Taylor et al., 2020 | ||
| rps29hi2903Tg/+ (AB) | Heterozygous | Unknown | |||
| rps29hi2903Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| rps29hi2903Tg | Unknown | Unknown | Fig. for (hi2903) from Phenotype Annotation (1994-2006) | ||
| tp53zdf1/zdf1; rps29hi2903Tg/hi2903Tg | Complex | Fig. 5 from Taylor et al., 2012 | Fig. 5 from Taylor et al., 2012 | ||
| tp53zdf1/zdf1; rps29hi2903Tg/+ | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Taylor, A.M., Macari, E.R., Chan, I.T., Blair, M.C., Doulatov, S., Vo, L.T., Raiser, D.M., Siva, K., Basak, A., Pirouz, M., Shah, A.N., McGrath, K., Humphries, J.M., Stillman, E., Alter, B.P., Calo, E., Gregory, R.I., Sankaran, V.G., Flygare, J., Ebert, B.L., Zhou, Y., Daley, G.Q., Zon, L.I. (2020) Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Science Translational Medicine. 12(566):
- Mirabello, L., Macari, E.R., Jessop, L., Ellis, S.R., Myers, T., Giri, N., Taylor, A.M., McGrath, K.E., Humphries, J.M., Ballew, B.J., Yeager, M., Boland, J.F., He, J., Hicks, B.D., Burdett, L., Alter, B.P., Zon, L., Savage, S.A. (2014) Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multi-case Diamond-Blackfan anemia families. Blood. 124(1):24-32
- Yen, J., White, R.M., Wedge, D.C., Van Loo, P., de Ridder, J., Capper, A., Richardson, J., Jones, D., Raine, K., Watson, I.R., Wu, C.J., Cheng, J., Martincorena, I., Nik-Zainal, S., Mudie, L., Moreau, Y., Marshall, J., Ramakrishna, M., Tarpey, P., Shlien, A., Whitmore, I., Gamble, S., Latimer, C., Langdon, E., Kaufman, C., Dovey, M., Taylor, A., Menzies, A., McLaren, S., O Meara, S., Butler, A., Teague, J., Lister, J., Chin, L., Campbell, P., Adams, D.J., Zon, L.I., Patton, E.E., Stemple, D.L., and Futreal, P.A. (2013) The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome biology. 14(10):R113
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Beert, E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius, E., Hopkins, N., and Lees, J.A. (2013) Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genetics. 9(8):e1003734
- Taylor, A.M., Humphries, J.M., White, R.M., Murphey, R.D., Burns, C.E., and Zon, L.I. (2012) Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Experimental hematology. 40(3):228-237
- Adatto, I., Lawrence, C., Thompson, M., and Zon, L.I. (2011) A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos. PLoS One. 6(6):e21715
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Lees, J.A., and Hopkins, N. (2010) Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences of the United States of America. 107(39):16940-16945
- Burns, C.E., Galloway, J.L., Smith, A.C., Keefe, M.D., Cashman, T.J., Paik, E.J., Mayhall, E.A., Amsterdam, A.H., and Zon, L.I. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 113(23):5776-5782
- Lai, K., Amsterdam, A., Farrington, S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):76-85
- MacInnes, A.W., Amsterdam, A., Whittaker, C.A., Hopkins, N., and Lees, J.A. (2008) Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proceedings of the National Academy of Sciences of the United States of America. 105(30):10408-10413
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