Genomic Feature
hu715
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 17: 19431699 (GRCz11) (1) Details
- Nucleotide change
- C/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>T at position 4246 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Glu>Stop at position 1416 (1)
- Flanking Sequence
-
GAACATGCAGCGTGGTGGGATCTTCAGCCAGCCGTACTGGAGCTCGGCAGAGCCTCCCGAACTCTGCTTCTCCGGTGGTAGCACCTTCAGGCCCAGAGAGCAGAGAAACAGCTGAGCCGCTCGCTCACCACAGCTGGTCAGATAGCAGCCCAGCAGAGCCTCCACACAGTCCGCTATGCTCTTATCTGCGATGCACTGCTCCGTGTGAAGGTCATAAGAGATGGACTGTTTCCCGATGTCCGTGCCGCAGTTTTCCTCAGAGGGATTCCAGAAGCCCACCACGAAATCGTCCTCCTCACCTGCTTTACTGGGGTCCAGGTAACACATGGCGTCCCAGGAGCTGTAATCGAACTCGTCAGCACCCCCGTCTGGCGAGAAGTGGGAGTTGTGGGCTTTTTTAGGAGCTTTCCATTCGTAGCCGGGGTCTGTGGGCTGGAGGGAGATCTTCTTGCCGAAAGCGCCAGAGCCGATTAACATGCTGTCGATGAAGCGGATGTGTT
C/A GTAATAATACTCCAGGTCGTCTTCAACATTTACATCTTCTTTAGATGGCTCGACCTCTGCTTCTTCCGGCTCATCATCGTCATCCTCGTCTTCGTCATCGCTGGCTTTTCCATTCGCTAAATCTTTATTCTGAAAAACAACAATAGAATTGGGCTTATGTTAAAGCTGAAAAAACAAAATGATACTAAATTATGAAAGGAAATGTTACAATCATCACCAAAACAATCATTAGTTATTATATATTGCTATATAATCTAATGTAAGACTATCCATTATTTTTATTAATTTTTAAACAACCATTATTTTACAACTATACAATACTACTACTATATTTATAATTGAAACTAACATTGGTTTTCCAAAATAATTAATAATATTTATAAAATTAAACATTTTATAATATTTATAACTTGTAAAAAAACAATACTGTTAATACAATACATTATAAACTGTTATATATTACAATTTTACACAATCGCAATTTTCTTTCAAATATAATC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dicer1hu715/hu715 | Homozygous | ♀-/- | 5 figures from 3 publications | 8 figures  from 6 publications | |
| dicer1hu715/hu715 | Homozygous | ♀+/- ♂+/- | |||
| dicer1hu715/hu715 | Homozygous | ♀-/- ♂-/- | Fig. 7 from Choi et al., 2008 | Fig. 7 from Choi et al., 2008 | |
| dicer1hu715/hu715 (TL) | Homozygous | Unknown | Fig. for (hu715) from Phenotype Annotation (1994-2006) | 5 figures from 2 publications | |
| dicer1hu715/+ | Heterozygous | Unknown | |||
| dicer1hu715 | Unknown | Unknown | |||
| dicer1hu715/hu715; wi124Tg | Complex | Fig. 6 from Shkumatava et al., 2009 | |||
| dicer1hu715/+; dicer1hu896/+ | Complex | ||||
| dicer1hu715/hu715 + MO3-lft2 | Complex | Fig. 3 from Choi et al., 2007 | |||
| dicer1hu715/hu715 + MO5-ndr1 | Complex | Fig. 3 from Choi et al., 2007 |
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Supplemental Information
- Genotyping protocol
- None
- Maerker, M., Getwan, M., Dowdle, M.E., McSheene, J.C., Gonzalez, V., Pelliccia, J.L., Hamilton, D.S., Yartseva, V., Vejnar, C., Tingler, M., Minegishi, K., Vick, P., Giraldez, A.J., Hamada, H., Burdine, R.D., Sheets, M.D., Blum, M., Schweickert, A. (2021) Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nature communications. 12:5482
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Gallagher, T.L., Tietz, K.T., Morrow, Z.T., McCammon, J.M., Goldrich, M.L., Derr, N.L., Amacher, S.L. (2017) Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Developmental Biology. 429(1):225-239
- Takacs, C.M., Giraldez, A.J. (2016) miR-430 regulates oriented cell division during neural tube development in zebrafish. Developmental Biology. 409(2):442-50
- Goudarzi, M., Strate, I., Paksa, A., Lagendijk, A.K., Bakkers, J., and Raz, E. (2013) On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling. Nature Genetics. 45(11):1264-1265
- Lewellis, S.W., Nagelberg, D., Subedi, A., Staton, A., Leblanc, M., Giraldez, A., and Knaut, H. (2013) Precise SDF1-mediated cell guidance is achieved through ligand clearance and microRNA-mediated decay. The Journal of cell biology. 200(3):337-355
- Moore, J.C., Sheppard, S., Shestopalov, I.A., Chen, J.K., and Lawson, N. (2013) Post-transcriptional mechanisms contribute to Etv2 repression during vascular development. Developmental Biology. 384(1):128-40
- Bazzini, A.A., Lee, M.T., and Giraldez, A.J. (2012) Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish. Science (New York, N.Y.). 336(6078):233-237
- Goudarzi, M., Banisch, T.U., Mobin, M.B., Maghelli, N., Tarbashevich, K., Strate, I., van den Berg, J., Blaser, H., Bandemer, S., Paluch, E., Bakkers, J., Toli-Nørrelykke, I.M., and Raz, E. (2012) Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility. Developmental Cell. 23(1):210-218
- Lim, S., Kumari, P., Gilligan, P., Quach, H.N., Mathavan, S., and Sampath, K. (2012) Dorsal activity of maternal squint is mediated by a non-coding function of the RNA. Development (Cambridge, England). 139(16):2903-2915
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