Genomic Feature
y10
- ID
- ZDB-ALT-030502-2
- Name
- y10
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Weinstein Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 2809317 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
-
Mutation in splice acceptor site.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- in Acceptor Splice Site (1)
- Transcript Consequence
- Splice Site (1)
- Protein Consequence
- None
- Flanking Sequence
-
ATCAGCGTTGTCAAATGTTAATGACGTAACCGCACTGATTCCGGAGCCTCTGAAAGTCCGCGAATGTTATGTGATACAGCACTGGAAAGCTGAGATTCTCTTCTTTATGCCAATATTTGAATTGTATGAATCGGATCAGCGGATCAAAAGTTATTAAACATTTAAGAGCAATACTTATTTTTAGCCGCGGGCGGCTGTCTCGGTCTTTAAGGGTTAAAACCGTTGATATGCAATTGTTCATGGTATGATAATCGTGCACGTTCAAATCGTGGTAGACCGTCATACCGGTATATTGTTACAACCCTAACCGTGATGCACCGAAATATCGAATTGAACCAAATCGATGGCATGATAATCGTAACCGAACCAAACCGTGAGACTAGTGTAGGTTCACAGCTCTAATAAAGATCATAATGTTCTTTCTTTCCTGTTCTGATTAAAACCTTTCTCGCGTGTAAAGACCACAGAAAAGCTCAAGTGTGTGTCCTGTGTCTCTTTCA
G/A TTGATATCCGGGAGATTAAGGAGATCCGGACTGGACAGAAGTCTCGGGACTTTGAGCGATATGTGGAGGACGTCACGACCCGGCCGGACCAGGCCCACTGCTTCGTCATCCTCTACGGCACTGAGTTTCGCCTCAAATCCCTCAGTCTGGCAGGTAAATCAGTATCATATGAGCGACACACACGTGTGCTTTAAACGTCGCATGAACTGTGATGTTTGATGTAATTTCAAGTGAAACATGAAGACCAGTGTTTCCCAACCCTGTTCCTGACGGCACACCAACACTACACGTTTTCAACCTCTCCCTATTCAAACACACCTGAATCAACTCAACAGAACATTAGAAGAGGCATCAAACCTGAAATGAAAGGGTCGGATAAAGGAGACATCCAAAATATGTACTGTTGGTGTGCCTTCAGGAAGAGGGTTGGGAAACATTGATGGAGACAGGGTGGGACGTAAGGTAGATCCTCCCCTTTTAATATGAATGAATGGTTGAAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| plcg1y10/y10 | Homozygous | Unknown | Fig. for (y10)  from Phenotype Annotation (1994-2006) | text only from Lawson et al., 2003 | |
| plcg1y10/y10 | Homozygous | ♀+/- ♂+/- | |||
| plcg1y10/+ (AB) | Heterozygous | Unknown | |||
| plcg1y10/+; y1Tg/+ | Complex | Fig. 1 from Lim et al., 2011 | |||
| plcg1y10; y1Tg | Complex | ||||
| plcg1y10/+; y1Tg/y1Tg | Complex | ||||
| plcg1y10/y10; y1Tg | Complex | Fig. 8 from Hen et al., 2015 | |||
| plcg1y10/y10; y1Tg | Complex | Fig. S5 from Stratman et al., 2020 | |||
| plcg1y10; y1Tg + MO1-gipc1 + MO2-gipc1 | Complex | ||||
| plcg1y10/+; y1Tg/+ + MO2-ntn1a | Complex | Fig. 1 from Lim et al., 2011 | Fig. 1 from Lim et al., 2011 |
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Supplemental Information
- Genotyping protocol
- None
- Stratman, A.N., Farrelly, O.M., Mikelis, C.M., Miller, M.F., Wang, Z., Pham, V.N., Davis, A.E., Burns, M.C., Pezoa, S.A., Castranova, D., Yano, J.J., Kilts, T.M., Davis, G.E., Gutkind, J.S., Weinstein, B.M. (2020) Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling. Nature communications. 11:1204
- Ferri-Lagneau, K.F., Haider, J., Sang, S., Leung, T. (2019) Rescue of hematopoietic stem/progenitor cells formation in plcg1 zebrafish mutant. Scientific Reports. 9:244
- Hen, G., Nicenboim, J., Mayseless, O., Asaf, L., Shin, M., Busolin, G., Hofi, R., Almog, G., Tiso, N., Lawson, N.D., Yaniv, K. (2015) Venous-derived angioblasts generate organ-specific vessels during embryonic development. Development (Cambridge, England). 142(24):4266-78
- Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61
- Lim, A.H., Suli, A., Yaniv, K., Weinstein, B., Li, D.Y., and Chien, C.B. (2011) Motoneurons are essential for vascular pathfinding. Development (Cambridge, England). 138(17):3847-3857
- Hermans, K., Claes, F., Vandevelde, W., Zheng, W., Geudens, I., Orsenigo, F., De Smet, F., Gjini, E., Anthonis, K., Ren, B., Kerjaschki, D., Autiero, M., Ny, A., Simons, M., Dewerchin, M., Schulte-Merker, S., Dejana, E., Alitalo, K., and Carmeliet, P. (2010) Role of synectin in lymphatic development in zebrafish and frogs. Blood. 116(17):3356-3366
- Covassin, L.D., Siekmann, A.F., Kacergis, M.C., Laver, E., Moore, J.C., Villefranc, J.A., Weinstein, B.M., and Lawson, N.D. (2009) A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Developmental Biology. 329(2):212-226
- Bayliss, P.E., Bellavance, K.L., Whitehead, G.G., Abrams, J.M., Aegerter, S., Robbins, H.S., Cowan, D.B., Keating, M.T., O'reilly, T., Wood, J.M., Roberts, T.M., and Chan, J. (2006) Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nature Chemical Biology. 2(5):265-273
- Gering, M., and Patient, R. (2005) Hedgehog Signaling Is Required for Adult Blood Stem Cell Formation in Zebrafish Embryos. Developmental Cell. 8(3):389-400
- Lawson, N.D., Mugford, J.W., Diamond, B.A., and Weinstein, B.M. (2003) phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes & Development. 17(11):1346-1351
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