Genomic Feature
hi258Tg
- ID
- ZDB-ALT-020430-44
- Name
- hi258Tg
- Synonyms
-
- hi258 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 21: 5880417 - 5880418 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rpl35hi258Tg/hi258Tg | Homozygous | ♀+/- ♂+/- | 2 figures from 2 publications | ||
| rpl35hi258Tg/+ | Heterozygous | Unknown | 2 figures  from 2 publications | ||
| rpl35hi258Tg/+ (AB) | Heterozygous | Unknown | |||
| rpl35hi258Tg/+ (AB/TU) | Heterozygous | Unknown | 3 figures from Lai et al., 2009 | ||
| rpl35hi258Tg | Unknown | Unknown | Fig. for (hi258) from Phenotype Annotation (1994-2006) | Fig. 4 from Amsterdam et al., 2004 | |
| reckw12/+; rpl35hi258Tg/+ | Complex | Fig. S1 from Kumari et al., 2018 |
1 - 6 of 6
Show
Supplemental Information
- Genotyping protocol
- hi258tg.pdf
- Kumari, R., Silic, M.R., Jones-Hall, Y.L., Nin-Velez, A., Yang, J.Y., Mittal, S.K., Zhang, G. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors.. Oncotarget. 9:23494-23504
- Silic, M.R., Zhang, G. (2018) Visualization of Cellular Electrical Activity in Zebrafish Early Embryos and Tumors. Journal of visualized experiments : JoVE. (134)
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Beert, E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius, E., Hopkins, N., and Lees, J.A. (2013) Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genetics. 9(8):e1003734
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Lees, J.A., and Hopkins, N. (2010) Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences of the United States of America. 107(39):16940-16945
- Lai, K., Amsterdam, A., Farrington, S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):76-85
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S., Bronson, R.T., Lees, J.A., and Hopkins, N. (2004) Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biology. 2(5):E139
- Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140
1 - 8 of 8
Show