Genomic Feature
hi1640Tg
- ID
- ZDB-ALT-011018-4
- Name
- hi1640Tg
- Synonyms
-
- hi1640 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion
- Protocol
- DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 4: 14972096 - 14972097 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Exon 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| smohi1640Tg/hi1640Tg | Homozygous | Unknown | Fig. 8  from Lu et al., 2020 | Fig. 3. from Pereira Piedade et al., 2019 | |
| smohi1640Tg/hi1640Tg | Homozygous | ♀+/- ♂+/- | 7 figures from 6 publications | 21 figures from 12 publications | |
| smohi1640Tg/hi1640Tg | Homozygous | ♀-/- | |||
| smohi1640Tg/+ | Heterozygous | ♀+/- ♂+/- | Fig. 2 from Poon et al., 2008 | ||
| smohi1640Tg/+ | Heterozygous | Unknown | |||
| smohi1640Tg/+ (AB) | Heterozygous | Unknown | |||
| smohi1640Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| smohi1640Tg | Unknown | Unknown | 8 figures from 3 publications | 7 figures from 3 publications | |
| smohi1640Tg/hi1640Tg; s854Tg | Complex | Fig. 2 from Chung et al., 2008 | |||
| smohi1640Tg/hi1640Tg; s903Tg | Complex | Fig. 2 from Chung et al., 2008 |
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Supplemental Information
- Genotyping protocol
- hi1640tg.pdf
- Mendieta-Serrano, M.A., Dhar, S., Ng, B.H., Narayanan, R., Lee, J.J.Y., Ong, H.T., Toh, P.J.Y., Röllin, A., Roy, S., Saunders, T.E. (2022) Slow muscles guide fast myocyte fusion to ensure robust myotome formation despite the high spatiotemporal stochasticity of fusion events. Developmental Cell. 57(17):2095-2110.e5
- Arveseth, C.D., Happ, J.T., Hedeen, D.S., Zhu, J.F., Capener, J.L., Klatt Shaw, D., Deshpande, I., Liang, J., Xu, J., Stubben, S.L., Nelson, I.B., Walker, M.F., Kawakami, K., Inoue, A., Krogan, N.J., Grunwald, D.J., Hüttenhain, R., Manglik, A., Myers, B.R. (2021) Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biology. 19:e3001191
- Tschaikner, P., Regele, D., Röck, R., Salvenmoser, W., Meyer, D., Bouvier, M., Geley, S., Stefan, E., Aanstad, P. (2021) Feedback Control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish. Development (Cambridge, England). 148(4):
- Lu, H., Shagirova, A., Goggi, J.L., Yeo, H.L., Roy, S. (2020) Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine. Biology Open. 9(5):
- Hartwell, R.D., England, S.J., Monk, N.A.M., van Hateren, N.J., Baxendale, S., Marzo, M., Lewis, K.E., Whitfield, T.T. (2019) Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genetics. 15:e1008051
- Hoshijima, K., Jurynec, M.J., Klatt Shaw, D., Jacobi, A.M., Behlke, M.A., Grunwald, D.J. (2019) Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. Developmental Cell. 51(5):645-657.e4
- Pereira Piedade, W., Veith, S., Famulski, J.K. (2019) Ubiquitin-mediated proteasome degradation regulates optic fissure fusion. Biology Open. 8(6):
- Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
- Pickering, J., Cunliffe, V.T., Van Eeden, F., Borycki, A.G. (2017) Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm. Matrix biology : journal of the International Society for Matrix Biology. 62:58-74
- Roberson, S., Halpern, M.E. (2017) Convergence of signaling pathways underlying habenular formation and axonal outgrowth. Development (Cambridge, England). 144(14):2652-2662
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