Genomic Feature
b641
- ID
- ZDB-ALT-000821-2
- Name
- b641
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Westerfield Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
(
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 4: 14973999 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Gly>Arg at position 242 (1)
- Flanking Sequence
-
TAGTGGAGTGAATCATGTATAAAGTTTAACAAATTTCAAGCATTGATAAATACAATAGACAAAAGAAAAACTAAATAAACACTGCTTTATGATATTCTGGGGAGTCTCTTACAGTATTCAGGTTCAAATACTGAATAGTAAATGTAAAACAACACACTAGTCTTCATTGCATAAATATTAAAAAATTATATCTTTGTTAAACTTACAAATGGTACAACTTCTTGTGCCTGAACGCTTTAAACTTCCTCTAACATTGCTCCAACATCACATTGTTCTATAAAGCAGTCATTTACATTGTTGTTGGGGAAACATTCGCCTGGCTGACTTCCTGGTTTCCAGTATTTTTGACAGAAAGTAGCTGAAGTTTTGGCCTGGAGATTCTAATATTGAACGTTGTTCCTTCTTACAATTTCCAACAGGCCACATTTCTTGCAGACTGGAAGAATTCCAACCGTTACCCCGCTGTGATCCTCTTTTACGTCAACGCCTGTTTCTTCATT
G/A GAAGTATTGGATGGCTCGCTCAATTCATGGATGGAGCCCGCAATGAGATAGTATGCAAAAGCGACAACACTATGCGACTTGGAGAGCCATCGTGAGTAAAAAATCCACCTTTCAAAAAAATTGAATAACAGTAAATTAGAGTTATACATTTTACAGTCAGCAAATTAATTATCATGGACAATACTAACAATATAATCAGTACTTACTCAATTTTTGGGATGCAAAAAACGATTTTCAAGAGGCTTGTTTTTCTTCTAGATCCACCGAGACGCTGTCATGCGTGATTATCTTCGTCATTGTGTATTACTCGCTTATGTCTGGAGTTATTTGGTTCGTTATGCTCACTTATGCCTGGCACACATCATTCAAAGCCCTTGGCACCACCCATCAGCCTCTGTCTGGAAAAACGTCCTATTTCCACTTGGTCACGTGGTCTATTCCTTTTATACTGACCGTTGCTATACTGGCCAATTCACAGGTGAGACAACTCTTACACTTTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| smob641/b641 | Homozygous | ♀+/- ♂+/- | 15 figures  from 13 publications | 37 figures from 21 publications | |
| smob641/b641 | Homozygous | Unknown | 2 figures from 2 publications | ||
| smob641/b641 (AB) | Homozygous | Unknown | 19 figures from 7 publications | 45 figures from 29 publications | |
| smob641/b641 (AB) | Homozygous | ♀+/- ♂+/- | 2 figures from 2 publications | 8 figures from 5 publications | |
| smob641/+ | Heterozygous | Unknown | Fig. 6 from Yin et al., 2012 | Fig. 6 from Yin et al., 2012 | |
| smob641/+ (AB) | Heterozygous | Unknown | |||
| smob641 | Unknown | Unknown | Fig. 7 from Lee et al., 2006 | ||
| smob641/b641; Df(Chr07)t4/t4 (AB) | Complex | Fig. 1 from Lewis et al., 2001 | Fig. 1 from Lewis et al., 2001 | ||
| smob641/b641; gz2Tg | Complex | Fig. 1 from Korzh et al., 2021 | Fig. 1 from Korzh et al., 2021 | ||
| smob641/b641; gz15Tg | Complex | Fig. 2 from Korzh et al., 2021 | Fig. 2 from Korzh et al., 2021 |
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Supplemental Information
- Genotyping protocol
- b641.pdf
- Wang, R., Guo, S., Yang, L. (2022) Tal2 is required for generation of GABAergic neurons in the zebrafish midbrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(2):263-275
- Juárez-Morales, J.L., Weierud, F., England, S.J., Demby, C., Santos, N., Grieb, G., Mazan, S., Lewis, K.E. (2021) Evolution of lbx spinal cord expression and function. Evolution & development. 23(5):404-422
- Korzh, S., Winata, C.L., Gong, Z., Korzh, V. (2021) The development of zebrafish pancreas affected by deficiency of Hedgehog signaling. Gene expression patterns : GEP. 41:119185
- Osborn, D.P.S., Li, K., Cutty, S.J., Nelson, A.C., Wardle, F.C., Hinits, Y., Hughes, S.M. (2020) Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Development (Cambridge, England). 147(8):
- Hartwell, R.D., England, S.J., Monk, N.A.M., van Hateren, N.J., Baxendale, S., Marzo, M., Lewis, K.E., Whitfield, T.T. (2019) Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genetics. 15:e1008051
- Tlili, S., Yin, J., Rupprecht, J.F., Mendieta-Serrano, M.A., Weissbart, G., Verma, N., Teng, X., Toyama, Y., Prost, J., Saunders, T.E. (2019) Shaping the zebrafish myotome by intertissue friction and active stress. Proceedings of the National Academy of Sciences of the United States of America. 116(51):25430-25439
- Yin, J., Lee, R., Ono, Y., Ingham, P.W., Saunders, T.E. (2018) Spatiotemporal Coordination of FGF and Shh Signaling Underlies the Specification of Myoblasts in the Zebrafish Embryo. Developmental Cell. 46:735-750.e4
- Weiss, O., Kaufman, R., Mishani, E., Inbal, A. (2017) Ocular vessel patterning in zebrafish is indirectly regulated by Hedgehog signaling. The International journal of developmental biology. 61:277-284
- Cooper, T.K., Spitsbergen, J.M. (2016) Valvular and Mural Endocardiosis in Aging Zebrafish (Danio rerio). Veterinary Pathology. 53(2):504-9
- Halluin, C., Madelaine, R., Naye, F., Peers, B., Roussigné, M., Blader, P. (2016) Habenular Neurogenesis in Zebrafish Is Regulated by a Hedgehog, Pax6 Proneural Gene Cascade. PLoS One. 11:e0158210
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