ZFIN Person: Whitfield, Tanya T.

ZFIN ID: ZDB-PERS-960805-607

ZFIN ID: ZDB-PERS-960805-607

Whitfield, Tanya T.

Email:	t.whitfield@sheffield.ac.uk
URL:	https://www.sheffield.ac.uk/bms/research/whitfield
Affiliation:	Whitfield Lab
Address:	Professor of Developmental Biology Department of Biomedical Science University of Sheffield SHEFFIELD S10 2TN UK
Country:	United Kingdom
Phone:	44-114-222-2350
Fax:	+44 114 222 2787
ORCID ID:	0000-0003-1575-1504

BIOGRAPHY AND RESEARCH INTERESTS

Development of vertebrate sensory systems, including the inner ear, lateral line and olfactory system. Please see my web page for details.

PUBLICATIONS

Asad, A., Shahidan, N.O., de la Vega de León, A., Wiggin, G.R., Whitfield, T.T., Baxendale, S. (2023) A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos. Basic & Clinical Pharmacology & Toxicology. 133(4):364-377

Baldera, D., Baxendale, S., van Hateren, N.J., Marzo, M., Glendenning, E., Geng, F.S., Yokoya, K., Knight, R.D., Whitfield, T.T. (2023) Enhancer trap lines with GFP driven by smad6b and frizzled1 regulatory sequences for the study of epithelial morphogenesis in the developing zebrafish inner ear. Journal of anatomy. 243(1):78-89

Jones, A.A., Diamantopoulou, E., Baxendale, S., Whitfield, T.T. (2022) Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Frontiers in cell and developmental biology. 10:959624

Crouzier, L., Richard, E.M., Diez, C., Alzaeem, H., Denus, M., Cubedo, N., Delaunay, T., Glendenning, E., Baxendale, S., Liévens, J.C., Whitfield, T.T., Maurice, T., Delprat, B. (2022) Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Human molecular genetics. 31(16):2711-2727

Mendonca, T., Jones, A.A., Pozo, J.M., Baxendale, S., Whitfield, T.T., Frangi, A.F. (2021) Origami: Single-cell 3D shape dynamics oriented along the apico-basal axis of folding epithelia from fluorescence microscopy data. PLoS Computational Biology. 17:e1009063

Kenyon, E.J., Kirkwood, N.K., Kitcher, S.R., Goodyear, R.J., Derudas, M., Cantillon, D.M., Baxendale, S., de la Vega de León, A., Mahieu, V.N., Osgood, R.T., Donald Wilson, C., Bull, J.C., Waddell, S.J., Whitfield, T.T., Ward, S.E., Kros, C.J., Richardson, G.P. (2021) Identification of a novel series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI insight. 6(7)

Baxendale, S., Asad, A., Shahidan, N.O., Wiggin, G.R., Whitfield, T.T. (2021) The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model. Genesis (New York, N.Y. : 2000). 59(4):e23417

Cheung, K.Y., Jesuthasan, S.J., Baxendale, S., van Hateren, N.J., Marzo, M., Hill, C.J., Whitfield, T.T. (2021) Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection. Frontiers in Physiology. 12:626080

Whitfield, T.T. (2020) Cilia in the developing zebrafish ear. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 375:20190163

Diamantopoulou, E., Baxendale, S., de la Vega de León, A., Asad, A., Holdsworth, C.J., Abbas, L., Gillet, V.J., Wiggin, G.R., Whitfield, T.T. (2019) Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. eLIFE. 8:

Hartwell, R.D., England, S.J., Monk, N.A.M., van Hateren, N.J., Baxendale, S., Marzo, M., Lewis, K.E., Whitfield, T.T. (2019) Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genetics. 15:e1008051

Kenyon, E.J., Kirkwood, N.K., Kitcher, S.R., O'Reilly, M., Derudas, M., Cantillon, D.M., Goodyear, R.J., Secker, A., Baxendale, S., Bull, J.C., Waddell, S.J., Whitfield, T.T., Ward, S.E., Kros, C.J., Richardson, G.P. (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. JCI insight. 2(24)

Alsina, B., Whitfield, T.T. (2017) Sculpting the labyrinth: morphogenesis of the developing inner ear. Seminars in cell & developmental biology. 65:47-59

Baxendale, S., Whitfield, T.T. (2016) Methods to study the development, anatomy, and function of the zebrafish inner ear across the life course. Methods in cell biology. 134:165-209

Stooke-Vaughan, G.A., Obholzer, N.D., Baxendale, S., Megason, S.G., Whitfield, T.T. (2015) Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin. Development (Cambridge, England). 142(6):1137-45

Maier, E.C., Whitfield, T.T. (2014) RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities. PLoS Genetics. 10:e1004858

Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374

Whitfield, T.T. (2013) Shedding new light on the origins of olfactory neurons. eLIFE. 2:e00648

Stooke-Vaughan, G.A., Huang, P., Hammond, K.L., Schier, A.F., and Whitfield, T.T. (2012) The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development (Cambridge, England). 139(10):1777-1787

Buck, L.M., Winter, M.J., Redfern, W.S., and Whitfield, T.T. (2012) Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Hearing Research. 284(1-2):67-81

Hammond, K.L., and Whitfield, T.T. (2011) Fgf and Hh signalling act on a symmetrical pre-pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle. Development (Cambridge, England). 138:3977-3987

Abbas, L., Hajihashemi, S., Stead, L.F., Cooper, G.J., Ware, T.L., Munsey, T.S., Whitfield, T.T., and White, S.J. (2011) Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1. The Journal of physiology. 589(Pt 6):1489-503

Hammond, K.L., van Eeden, F.J., and Whitfield, T.T. (2010) Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle. Development (Cambridge, England). 137(8):1361-1371

Hammond, K.L., and Whitfield, T.T. (2009) Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterning. Gene expression patterns : GEP. 9(6):391-396

Abbas, L., and Whitfield, T.T. (2009) Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva. Development (Cambridge, England). 136(16):2837-2848

Hammond, K.L., Loynes, H.E., Mowbray, C., Runke, G., Hammerschmidt, M., Mullins, M.C., Hildreth, V., Chaudhry, B., and Whitfield, T.T. (2009) A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS One. 4(2):e4368

Dutton, K., Abbas, L., Spencer, J., Brannon, C., Mowbray, C., Nikaido, M., Kelsh, R.N., and Whitfield, T.T. (2009) A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle. Disease models & mechanisms. 2(1-2):68-83

Hammond, K.L., Baxendale, S., McCauley, D.W., Ingham, P.W., and Whitfield, T.T. (2009) Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling. Evolution & development. 11(1):27-40

Whitfield, T.T., and Hammond, K.L. (2007) Axial patterning in the developing vertebrate inner ear. The International journal of developmental biology. 51(6-7):507-520

Hammond, K.L., and Whitfield, T.T. (2006) The developing lamprey ear closely resembles the zebrafish otic vesicle: otx1 expression can account for all major patterning differences. Development (Cambridge, England). 133(7):1347-1357

Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M. (2005) Models of congenital deafness: Mouse and zebrafish. Drug discovery today. 2(2):85-92

Whitfield, T.T. (2005) Lateral line: precocious phenotypes and planar polarity. Current biology : CB. 15(2):R67-70

Kozlowski, D.J., Whitfield, T.T., Hukriede, N.A., Lam, W.K., and Weinberg, E.S. (2005) The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Developmental Biology. 277(1):27-41

Hammond, K.L., Loynes, H.E., Folarin, A.A., Smith, J., and Whitfield, T.T. (2003) Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle. Development (Cambridge, England). 130(7):1403-1417

Whitfield, T.T. (2002) Zebrafish as a model for hearing and deafness. Journal of neurobiology. 53(2):157-171

Whitfield, T.T., Riley, B.B., Chiang, M.-Y., and Phillips, B. (2002) Development of the zebrafish inner ear. Developmental Dynamics : an official publication of the American Association of Anatomists. 223(4):427-458

Hammond, K.L., Hill, R.E., Whitfield, T.T., and Currie, P.D. (2002) Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds. Mechanisms of Development. 112(1-2):183-189

Mowbray, C., Hammerschmidt, M., and Whitfield, T.T. (2001) Expression of BMP signalling pathway members in the developing zebrafish inner ear and lateral line. Mechanisms of Development. 108(1-2):179-184

Whitfield-T. (1999) The New Fish Cook Books: The Zebrafish: Biology (Methods in Cell Biology, Vol. 59), The Zebrafish: Genetics and Genomics (Methods in Cell Biology, Vol. 60) edited by H. William Detrich, III, Monte Westerfield and Leonard I. Zon. Trends in cell biology. 9(11):464-465

Haddon, C., Mowbray, C., Whitfield, T., Jones, D., Gschmeissner, S., and Lewis, J. (1999) Hair cells without supporting cells: further studies in the ear of the zebrafish mind bomb mutant. Journal of neurocytology. 28(10-11):837-850

Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., and Johnson, S.L. (1999) Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development (Cambridge, England). 126(15):3425-3436

Whitfield, T., Haddon, C., and Lewis, J. (1997) Intercellular signals and cell-fate choices in the developing inner ear: origins of global and of fine-grained pattern. Seminars in cell & developmental biology. 8(3):239-247

Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254

NON-ZEBRAFISH PUBLICATIONS
Whitfield, T. T., Heasman, J. and Wylie, C. C. (1995). Early embryonic expression of XLPOU-60, a Xenopus POU-domain protein. Developmental Biology 169, 759-769.

Whitfield, T. T., Sharpe, C. R. and Wylie. C. C. (1994). Nonsense-mediated mRNA decay in Xenopus oocytes and embryos. Developmental Biology 165, 731-734.

Whitfield, T., Heasman, J. and Wylie, C. (1993). XLPOU-60, a Xenopus POU-domain mRNA, is oocyte-specific from very early stages of oogenesis and localised to presumptive mesoderm and ectoderm in the blastula. Developmental Biology 155, 361-370.