ZFIN Lab: Group of Animal Morphogenesis During Development

ZFIN ID: ZDB-LAB-970424-82

Group of Animal Morphogenesis During Development

PI/Director:	Takeda, Hiroyuki
Contact Person:	Takeda, Hiroyuki
Email:	htakeda@lab.nig.ac.jp
URL:	http://www.nig.ac.jp/labs/EarlyEmb/
Address:	Department of Biological Sciences Graduate School of Science University of Tokyo Hongo 7-3-1, Bunkyo-ku Tokyo, 113-0033 Japan
Country:	Japan
Phone:	81-559-81-6739
Fax:	81-559-81-6740
Line Designation:	ja

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 9 genomic features

STATEMENT OF RESEARCH INTERESTS

Axis formation in early zebrafish development.

LAB MEMBERS

Sawada, Atsushi Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Du, J., Li, S.K., Guan, L.Y., Guo, Z., Yin, J.F., Gao, L., Kawanishi, T., Shimada, A., Zhang, Q.P., Zheng, L.S., Liu, Y.Y., Feng, X.Q., Zhao, L., Chen, D.Y., Takeda, H., Fan, Y.B. (2023) Mechanically sensitive HSF1 is a key regulator of left-right symmetry breaking in zebrafish embryos. iScience. 26:107864107864

Liu, S., Kawanishi, T., Shimada, A., Ikeda, N., Yamane, M., Takeda, H., Tasaki, J. (2023) Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model. Toxicological sciences : an official journal of the Society of Toxicology. 196(1):38-51

Ikeda, T., Inamori, K., Kawanishi, T., Takeda, H. (2022) Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation. Development, growth & differentiation. 64(3):163-177

Wu, X., Zhang, H., Zhang, B., Zhang, Y., Wang, Q., Shen, W., Wu, X., Li, L., Xia, W., Nakamura, R., Liu, B., Liu, F., Takeda, H., Meng, A., Xie, W. (2021) Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. Science advances. 7:eabl3858

Nakamura, R., Motai, Y., Kumagai, M., Wike, C.L., Nishiyama, H., Nakatani, Y., Durand, N.C., Kondo, K., Kondo, T., Tsukahara, T., Shimada, A., Cairns, B.R., Lieberman Aiden, E., Morishita, S., Takeda, H. (2021) CTCF looping is established during gastrulation in medaka embryos. Genome research. 31(6):968-980

Nakagama, Y., Takeda, N., Ogawa, S., Takeda, H., Furutani, Y., Nakanishi, T., Sato, T., Hirata, Y., Oka, A., Inuzuka, R. (2019) Noonan syndrome-associated biallelic LZTR1 mutations cause cardiac hypertrophy and vascular malformations in zebrafish. Molecular genetics & genomic medicine. 8(3):e1107

Abe, K., Shimada, A., Tayama, S., Nishikawa, H., Kaneko, T., Tsuda, S., Karaiwa, A., Matsui, T., Ishitani, T., Takeda, H. (2019) Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite. Cell Reports. 27:928-939.e4

Yamaguchi, H., Oda, T., Kikkawa, M., Takeda, H. (2018) Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly. eLIFE. 7

Williams, M.L.K., Sawada, A., Budine, T., Yin, C., Gontarz, P., Solnica-Krezel, L. (2018) Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes. Nature communications. 9:1319

Uchida, Y., Uesaka, M., Yamamoto, T., Takeda, H., Irie, N. (2018) Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos. EvoDevo. 9:7

Nakamura, R., Uno, A., Kumagai, M., Morishita, S., Takeda, H. (2017) Hypomethylated domain-enriched DNA motifs prepattern the accessible nucleosome organization in teleosts. Epigenetics & chromatin. 10:44

Moriyama, Y., Ito, F., Takeda, H., Yano, T., Okabe, M., Kuraku, S., Keeley, F.W., Koshiba-Takeuchi, K. (2016) Evolution of the fish heart by sub/neofunctionalization of an elastin gene. Nature communications. 7:1039710397

Li-Villarreal, N., Forbes, M.M., Loza, A.J., Chen, J., Ma, T., Helde, K., Moens, C.B., Shin, J., Sawada, A., Hindes, A.E., Dubrulle, J., Schier, A.F., Longmore, G.D., Marlow, F.L., Solnica-Krezel, L. (2015) Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development (Cambridge, England). 142(15):2704-18

Yamamoto, T., Tsukahara, T., Ishiguro, T., Hagiwara, H., Taira, M., Takeda, H. (2015) The medaka dhc2 mutant reveals conserved and distinct mechanisms of Hedgehog signaling in teleosts. BMC Developmental Biology. 15:9

Liu, F., Bhang, S.H., Arentson, E., Sawada, A., Kim, C.K., Kang, I., Yu, J., Sakurai, N., Kim, S.H., Yoo, J.J., Kim, P., Pahng, S.H., Xia, Y., Solnica-Krezel, L., and Choi, K. (2013) Enhanced hemangioblast generation and improved vascular repair and regeneration from embryonic stem cells by defined transcription factors. Stem Cell Reports. 1(2):166-182

Sato, A., and Takeda, H. (2013) Neuronal Subtypes Are Specified by the Level of neurod Expression in the Zebrafish Lateral Line. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(2):556-562

Khan, A., Nakamoto, A., Okamoto, S., Tai, M., Nakayama, Y., Kobayashi, K., Kawamura, A., Takeda, H., and Yamasu, K. (2012) Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages. Mechanisms of Development. 129(9-12):219-235

Khan, A., Nakamoto, A., Tai, M., Saito, S., Nakayama, Y., Kawamura, A., Takeda, H., and Yamasu, K. (2012) Mesendoderm specification depends on the function of Pou2, the class V POU-type transcription factor, during zebrafish embryogenesis. Development, growth & differentiation. 54(7):686-701

Ishioka, A., Jindo, T., Kawanabe, T., Hatta, K., Parvin, M.S., Nikaido, M., Kuroyanagi, Y., Takeda, H., and Yamasu, K. (2011) Retinoic acid-dependent establishment of positional information in the hindbrain was conserved during vertebrate evolution. Developmental Biology. 350(1):154-168

Sato, A., Koshida, S., and Takeda, H. (2010) Single-cell analysis of somatotopic map formation in the zebrafish lateral line system. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):2058-2065

Ishimatsu, K., Takamatsu, A., and Takeda, H. (2010) Emergence of traveling waves in the zebrafish segmentation clock. Development (Cambridge, England). 137(10):1595-1599

Roszko, I., Sawada, A., and Solnica-Krezel, L. (2009) Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Seminars in cell & developmental biology. 20(8):986-997

Parvin, M.S., Okuyama, N., Inoue, F., Islam, M.E., Kawakami, A., Takeda, H., and Yamasu, K. (2008) Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(5):1373-1388

Nagayoshi, S., Hayashi, E., Abe, G., Osato, N., Asakawa, K., Urasaki, A., Horikawa, K., Ikeo, K., Takeda, H., and Kawakami, K. (2008) Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like. Development (Cambridge, England). 135(1):159-169

Ishimatsu, K., Horikawa, K., and Takeda, H. (2007) Coupling cellular oscillators: A mechanism that maintains synchrony against developmental noise in the segmentation clock. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(6):1416-1421

Yokoi, H., Shimada, A., Carl, M., Takashima, S., Kobayashi, D., Narita, T., Jindo, T., Kimura, T., Kitagawa, T., Kage, T., Sawada, A., Naruse, K., Asakawa, S., Shimizu, N., Mitani, H., Shima, A., Tsutsumi, M., Hori, H., Wittbrodt, J., Saga, Y., Ishikawa, Y., Araki, K., and Takeda, H. (2007) Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships. Developmental Biology. 304(1):326-337

Sasaki, T., Shimizu, A., Ishikawa, S.K., Imai, S., Asakawa, S., Murayama, Y., Khorasani, M.Z., Mitani, H., Furutani-Seiki, M., Kondoh, H., Nanda, I., Schmid, M., Schartl, M., Nonaka, M., Takeda, H., Hori, H., Himmelbauer, H., Shima, A., and Shimizu, N. (2007) The DNA sequence of medaka chromosome LG22. Genomics. 89(1):124-133

Islam, M.E., Kikuta, H., Inoue, F., Kanai, M., Kawakami, A., Parvin, M.S., Takeda, H., and Yamasu, K. (2006) Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development. Mechanisms of Development. 123(12):907-924

Sakaguchi, T., Kikuchi, Y., Kuroiwa, A., Takeda, H., and Stainier, D.Y. (2006) The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish. Development (Cambridge, England). 133(20):4063-4072

Horikawa, K., Ishimatsu, K., Yoshimoto, E., Kondo, S., and Takeda, H. (2006) Noise-resistant and synchronized oscillation of the segmentation clock. Nature. 441(7094):719-723

Kobayashi, D., Jindo, T., Naruse, K., and Takeda, H. (2006) Development of the endoderm and gut in medaka, Oryzias latipes. Development, growth & differentiation. 48(5):283-295

Okuda, Y., Yoda, H., Uchikawa, M., Furutani-Seiki, M., Takeda, H., Kondoh, H., Kamachi, Y. (2006) Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(3):811-825

Sawada, A., Nishizaki, Y., Sato, H., Yada, Y., Nakayama, R., Yamamoto, S., Nishioka, N., Kondoh, H., and Sasaki, H. (2005) Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Development (Cambridge, England). 132(21):4719-4729

Shimoda, N., Yamakoshi, K., Miyake, A., and Takeda, H. (2005) Identification of a gene required for de novo DNA methylation of the zebrafish no tail gene. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(4):1509-1516

Murayama, E., Herbomel, P., Kawakami, A., Takeda, H., and Nagasawa H. (2005) Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Mechanisms of Development. 122(6):791-803

Kawakami, A., Nojima, Y., Toyoda, A., Takahoko, M., Satoh, M., Tanaka, H., Wada, H., Masai, I., Terasaki, H., Sakaki, Y., Takeda, H., and Okamoto, H. (2005) The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Current biology : CB. 15(5):480-488

Kawahara, A., Che, Y.S., Hanaoka, R., Takeda, H., and Dawid, I.B. (2005) Zebrafish GADD45{beta} genes are involved in somite segmentation. Proceedings of the National Academy of Sciences of the United States of America. 102(2):361-366

Kawakami, A., Fukazawa, T., and Takeda, H. (2004) Early fin primordia of zebrafish larvae regenerate by a similar growth control mechanism with adult regeneration. Developmental Dynamics : an official publication of the American Association of Anatomists. 231(4):693-699

Kage, T., Takeda, H., Yasuda, T., Maruyama, K., Yamamoto, N., Yoshimoto, M., Araki, K., Inohaya, K., Okamoto, H., Yasumasu, S., Watanabe, K., Ito, H., and Ishikawa, Y. (2004) Morphogenesis and regionalization of the medaka embryonic brain. The Journal of comparative neurology. 476(3):219-239

Tanaka, K., Ohisa, S., Orihara, N., Sakaguchi, S., Horie, K., Hibiya, K., Konno, S., Miyake, A., Setiamarga, D., Takeda, H., Imai, Y., and Kudo, A. (2004) Characterization of mutations affecting embryonic hematopoiesis in the medaka, Oryzias latipes. Mechanisms of Development. 121(7-8):739-746

Sekimizu, K., Nishioka, N., Sasaki, H., Takeda, H., Karlstrom, R.O., and Kawakami, A. (2004) The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development (Cambridge, England). 131(11):2521-2532

Takeuchi, M., Nakabayashi, J., Sakaguchi, T., Yamamoto, T.S., Takahashi, H., Takeda, H., and Ueno, N. (2003) The prickle-related gene in vertebrates is essential for gastrulation cell movements. Current biology : CB. 13(8):674-679

Holley, S.A. and Takeda, H. (2002) Catching a wave: the oscillator and wavefront that create the zebrafish somite. Seminars in cell & developmental biology. 13(6):481-486

Takeda, H. (2002) Wave and somite segmentation: a view from zebrafish genetic analyses. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 47(15):2017-2023

Tonou-Fujimori, N., Takahashi, M., Onodera, H., Kikuta, H., Koshida, S., Takeda, H., and Yamasu, K. (2002) RETRACTED: Expression of the FGF receptor 2 gene (fgfr2) during embryogenesis in the zebrafish Danio rerio. Gene expression patterns : GEP. 2(3-4):183-188

Picker, A., Scholpp, S., Bohli, H., Takeda, H., and Brand, M. (2002) A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development (Cambridge, England). 129(13):3227-3239

Nikaido, M., Kawakami, A., Sawada, A., Furutani-Seiki, M., Takeda, H., and Araki, K. (2002) Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. Nature Genetics. 31(2):195-199

Nomura-Kitabayashi, A., Takahashi, Y., Kitajima, S., Inoue, T., Takeda, H., and Saga, Y. (2002) Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis. Development (Cambridge, England). 129(10):2473-2481

Koshida, S., Shinya, M., Nikaido, M., Ueno, N., Schulte-Merker, S., Kuroiwa, A., and Takeda, H. (2002) Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafish. Developmental Biology. 244(1):9-20

Sakaguchi, T., Mizuno, T., and Takeda, H. (2002) Formation and patterning roles of the yolk syncytial layer. Results and problems in cell differentiation. 40:1-14

Sawada, A., Shinya, M., Jiang, Y.J., Kawakami, A., Kuroiwa, A., and Takeda, H. (2001) Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development (Cambridge, England). 128(23):4873-4880

Shinya, M., Koshida, S., Sawada, A., Kuroiwa, A., and Takeda, H. (2001) Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos. Development (Cambridge, England). 128(21):4153-4164

Sakaguchi, T., Kuroiwa, A., and Takeda, H. (2001) A novel sox gene, 226D7, acts downstream of Nodal signaling to specify endoderm precursors in zebrafish. Mechanisms of Development. 107(1-2):25-38

Sakaguchi, T., Kuroiwa, A., and Takeda, H. (2001) Expression of zebrafish btg-b, an anti-proliferative cofactor, during early embryogenesis. Mechanisms of Development. 104(1-2):113-115

Sawada, A., Saga, Y., and Takeda, H. (2000) Zebrafish somitogenesis-roles of mesp- and hairy-related genes. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 45(17):2738-2744

Kondoh, H., Uchikawa, M., Yoda, H., Takeda, H., Furutani-Seiki, M., and Karlstrom, R.O. (2000) Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. Mechanisms of Development. 96(2):165-174

Sawada, A., Fritz, A., Jiang, Y., Yamamoto, A., Yamasu, K., Kuroiwa, A., Saga, Y., and Takeda, H. (2000) Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Development (Cambridge, England). 127(8):1691-1702

Ananuma, K., Takeda, H., Amanuma, H., and Aoki, Y. (2000) Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments. Nat. Biotechnol.. 18(1):62-65

Rodaway, A., Takeda, H., Koshida, S., Broadbent, J., Price, B., Smith, J.C., Patient, R., and Holder, N. (1999) Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-ß; family signals and discrimination of mesoderm and endoderm by FGF. Development (Cambridge, England). 126(14):3067-3078

Shinya, M., Furutani-Seiki, M., Kuroiwa, A., and Takeda, H. (1999) Mosaic analysis with oep mutant reveals a repressive interaction between floor-plate and non-floor-plate mutant cells in the zebrafish neural tube. Development, growth & differentiation. 41(2):135-142

Mizuno, T., Yamaha, E., Kuroiwa, A., and Takeda, H. (1999) Removal of vegetal yolk causes dorsal deficencies and impairs dorsal-inducing ability of the yolk cell in zebrafish. Mechanisms of Development. 81(1-2):51-63

Mizuno, T., Shinya, M., and Takeda, H. (1999) Cell and tissue transplantation in zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 127:15-28

Nikaido, M., Tada, M., Takeda, H., Kuroiwa, A., and Ueno, N. (1999) In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning. Development (Cambridge, England). 126:181-190

Kobayashi, M., Toyama, R., Takeda, H., Dawid, I.B., and Kawakami, K. (1998) Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development (Cambridge, England). 125:2973-2982

Yamanaka, Y., Mizuno, T., Sasai, Y., Kishi, M., Takeda, H., Kim, C.-H., Hibi, M., and Hirano, T. (1998) A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Genes & Development. 12:2345-2353

Yamaha, E., Mizuno, T., Hasebe, Y., Takeda, H., Yamazaki, F. (1998) Dorsal specification in blastoderm at the blastula stage in the goldfish, Carassius auratus. Development, growth & differentiation. 40(3):267-275

Koshida, S., Shinya, M., Mizuno, T., Kuroiwa, A., and Takeda, H. (1998) Initial anteroposterior pattern of the zebrafish central nervous system is determined by differential competence of the epiblast. Development (Cambridge, England). 125:1957-1966

Makita, R., Mizuno, T., Koshida, S., Kuroiwa, A., and Takeda, H. (1998) Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and no tail activity. Mechanisms of Development. 71:165-176

Mizuno, T., Yamaha, E., Wakahara, M., Kuroiwa, A., and Takeda, H. (1996) Mesoderm induction in zebrafish. Nature. 383(6596):131-132

Amanuma, K., Hamada, Y., and Takeda, H. (1995) Transgene expression and integration in the zebrafish, Danio rerio. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 40:2257-2264

Takeda, H. and Miyagawa, T. (1994) Commitment of cell fate in embryo of the zebrafish, Danio rerio. Fish Biol. J. Medaka. 6:33-45

Takeda, H., Matsuzaki, T., Oki, T., Miyagawa, T., and Amanuma, H. (1994) A novel POU domain gene, zebrafish pou2: expression and roles of two alternatively spliced twin products in early development. Genes & Development. 8:45-59

Matsuzaki, T., Amanuma, H., and Takeda, H. (1992) A POU-domain gene of zebrafish, ZFPOU1, specifically expressed in the developing neural tissues. Biochemical and Biophysical Research Communications. 187:1446-1453