ZFIN Lab: Tryggvason Lab

ZFIN ID: ZDB-LAB-150407-1

Tryggvason Lab

PI/Director:	Tryggvason, Karlynn
Co-PI / Senior Researcher:	He, Bing
Contact Person:	He, Bing
Email:	Bing.He@ki.se
URL:
Address:	Division of Matrix Biology Department of Medical Biochemistry and Biophysics Karolinska Institute Scheeles väg 2, B1, Plan 4 171 77 Stockholm Sweden
Country:	Sweden
Phone:	+46 8 52486341
Fax:
Line Designation:	ki

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

Genetics of diabetic nephropathy
Glomerular filtration barrier
Glomerular podocyte biology and its role in kidney glomerular diseases

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Tanoue, A., Katayama, K., Ito, Y., Joh, K., Toda, M., Yasuma, T., D'Alessandro-Gabazza, C.N., Kawachi, H., Yan, K., Ito, M., Gabazza, E.C., Tryggvason, K., Dohi, K. (2021) Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis. Scientific Reports. 11:20556

Lu, Q., Zhang, M.N., Shi, X.Y., Zhang, L.Q., Wang, Y.Y., Liu, L.Y., He, W., Chen, H.M., He, B., Zou, L.P. (2020) Association of HECW2 variants with developmental and epileptic encephalopathy and knockdown of zebrafish hecw2a. American journal of medical genetics. Part A. 185(2):377-383

Ito, Y., Katayama, K., Nishibori, Y., Akimoto, Y., Kudo, A., Kurayama, R., Hada, I., Takahashi, S., Kimura, T., Fukutomi, T., Katada, T., Suehiro, J., Beltcheva, O., Tryggvason, K., Yan, K. (2017) Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression. American journal of physiology. Renal physiology. 312(6):F1184-F1199

Sun, J., Hultenby, K., Axelsson, J., Nordström, J., He, B., Wernerson, A., Lindström, K. (2017) Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies. Kidney international reports. 2:721-732

Perisic, L., Rodriguez, P.Q., Hultenby, K., Sun, Y., Lal, M., Betsholtz, C., Uhlén, M., Wernerson, A., Hedin, U., Pikkarainen, T., Tryggvason, K., Patrakka, J. (2015) Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin. PLoS One. 10:e0122067

He, B., Ebarasi, L., Zhao, Z., Guo, J., Ojala, J.R., Hultenby, K., De Val, S., Betsholtz, C., Tryggvason, K. (2014) Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes. Journal of the American Society of Nephrology : JASN. 25(12):2764-77

Abu Seman, N., He, B., Ojala, J.R., Wan Mohamud, W.N., Ostenson, C.G., Brismar, K., Gu, H.F. (2014) Genetic and Biological Effects of Sodium-Chloride Cotransporter ( SLC12A3 ) in Diabetic Nephropathy. American journal of nephrology. 40:408-416

Mao, J., Wang, D., Mataleena, P., He, B., Niu, D., Katayama, K., Xu, X., Ojala, J.R., Wang, W., Shu, Q., Du, L., Liu, A., Pikkarainen, T., Patrakka, J., and Tryggvason, K. (2013) Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes. PLoS One. 8(8):e72750

He, B., Osterholm, A.M., Ojala, J.R., Andersson, A.C., and Tryggvason, K. (2013) A Remote Cis-Acting Variant at 3q Links Glomerular NCK1 to Diabetic Nephropathy. PLoS One. 8(2):e56414

Nishibori, Y., Katayama, K., Parikka, M., Oddsson, A., Nukui, M., Hultenby, K., Wernerson, A., He, B., Ebarasi, L., Raschperger, E., Norlin, J., Uhlén, M., Patrakka, J., Betsholtz, C., and Tryggvason, K. (2011) Glcci1 Deficiency Leads to Proteinuria. Journal of the American Society of Nephrology : JASN. 22(11):2037-46

He, B., Ebarasi, L., Hultenby, K., Tryggvason, K., and Betsholtz, C. (2011) Podocin-Green Fluorescence Protein Allows Visualization and Functional Analysis of Podocytes. Journal of the American Society of Nephrology : JASN. 22(6):1019-1023