ZFIN Lab: McDermott Lab

ZFIN ID: ZDB-LAB-070315-1

McDermott Lab

PI/Director:	McDermott Jr., Brian M.
Contact Person:	McDermott Jr., Brian M.
Email:	bmm30@case.edu
URL:
Address:	Case Western Reserve University Department of Otolaryngology 1100 Euclid Ave Wearn/452 Cleveland, Ohio 44106
Country:	United States
Phone:	216-844-6119
Fax:
Line Designation:	cwr

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 19 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Bai, Haimeng (Steven) Graduate Student	Davis, Robin Woods Graduate Student	Gupta, Nilay Graduate Student
Pollock, Lana Graduate Student	Sun, Shenyu (Shawn) Graduate Student	Wang, Shengxuan (Kelsi) Graduate Student
Zhu, Shaoyuan (Sara) Graduate Student	Zongwei, Cheng (Kevin) Graduate Student	Fernando, Carol Research Staff
Ko, Bona

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Kindig, K., Stepanyan, R., Kindt, K.S., McDermott, B.M. (2023) Asymmetric mechanotransduction by hair cells of the zebrafish lateral line. Current biology : CB. 33(7):1295-1307.e3

Zhu, S., Chen, Z., Wang, H., McDermott, B.M. (2021) Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear. Frontiers in cell and developmental biology. 8:570486

Pollock, L.M., Perkins, B., Anand-Apte, B. (2020) Primary cilia are present on endothelial cells of the hyaloid vasculature but are not required for the development of the blood-retinal barrier. PLoS One. 15:e0225351

Chen, Z., Zhu, S., Kindig, K., Wang, S., Chou, S.W., Davis, R.W., Dercoli, M.R., Weaver, H., Stepanyan, R., McDermott, B.M. (2020) Tmc proteins are essential for zebrafish hearing where Tmc1 is not obligatory. Human molecular genetics. 29(12):2004-2021

Gopal, S.R., Lee, Y.T., Stepanyan, R., McDermott, B.M., Alagramam, K.N. (2019) Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model. Proceedings of the National Academy of Sciences of the United States of America. 116(22):11000-11009

Pollock, L.M., Xie, J., Bell, B.A., Anand-Apte, B. (2018) Retinoic acid signaling is essential for maintenance of the blood-retinal barrier. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(10):5674-5684

Chou, S.W., Chen, Z., Zhu, S., Davis, R.W., Hu, J., Liu, L., Fernando, C.A., Kindig, K., Brown, W.C., Stepanyan, R., McDermott, B.M. (2017) A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish. Nature communications. 8:2234

Vargo, J.W., Walker, S.N., Gopal, S.R., Deshmukh, A.R., McDermott, B.M., Alagramam, K.N., Stepanyan, R. (2017) Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells. Frontiers in Cellular Neuroscience. 11:393

Chen, Z., Chou, S.W., McDermott, B.M. (2017) Ribeye protein is intrinsically dynamic but is stabilized in the context of the ribbon synapse. The Journal of physiology. 596(3):409-421

Pollock, L.M., Gupta, N., Chen, X., Luna, E.J., McDermott, B.M. (2016) Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. PLoS One. 11:e0158349

Hwang, P., Chou, S.W., Chen, Z., McDermott, B.M. (2015) The Stereociliary Paracrystal Is a Dynamic Cytoskeletal Scaffold In Vivo. Cell Reports. 13(7):1287-94

Gopal, S.R., Chen, D.H., Chou, S.W., Zang, J., Neuhauss, S.C., Stepanyan, R., McDermott, B.M., Alagramam, K.N. (2015) Zebrafish Models for the Mechanosensory Hair Cell Dysfunction in Usher Syndrome 3 Reveal That Clarin-1 Is an Essential Hair Bundle Protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:10188-201

Antonellis, P.J., Pollock, L.M., Chou, S.W., Hassan, A., Geng, R., Chen, X., Fuchs, E., Alagramam, K.N., Auer, M., and McDermott, B.M. (2014) ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(1):305-312

Balow, S.A., Pierce, L.X., Zentner, G.E., Conrad, P.A., Davis, S., Sabaawy, H.E., McDermott, B.M., and Scacheri, P.C. (2013) Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome. Developmental Biology. 382(1):57-69

Santos-Cortez, R.L., Lee, K., Azeem, Z., Antonellis, P.J., Pollock, L.M., Khan, S., Irfanullah, I., Andrade-Elizondo, P.B., Chiu, I., Adams, M.D., Basit, S., Smith, J.D., Nickerson, D.A., McDermott, B.M., Ahmad, W., and Leal, S.M. (2013) Mutations in KARS, Encoding Lysyl-tRNA Synthetase, Cause Autosomal-Recessive Nonsyndromic Hearing Impairment DFNB89. American journal of human genetics. 93(1):132-40

Werdich, A.A., Brzezinski, A., Jeyaraj, D., Ficker, E., Wan, X., McDermott, B.M., Sabeh, M.K., MacRae, C.A., and Rosenbaum, D.S. (2012) The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart. Progress in Biophysics and Molecular Biology. 110(2-3):154-165

West, M.C., and McDermott, B.M. Jr. (2011) Ribeye a-mCherry fusion protein: A novel tool for labeling synaptic ribbons of the hair cell. Journal of Neuroscience Methods. 197(2):274-8

Chou, S.W., Hwang, P., Gomez, G., Fernando, C.A., West, M.C., Pollock, L.M., Lin-Jones, J., Burnside, B., and McDermott, B.M. (2011) Fascin 2b Is a Component of Stereocilia that Lengthens Actin-Based Protrusions. PLoS One. 6(4):e14807

Fernando, C.A., Conrad, P.A., Bartels, C.F., Marques, T., To, M., Balow, S.A., Nakamura, Y., and Warman, M.L. (2010) Temporal and spatial expression of CCN genes in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(6):1755-1767

McDermott, B.M., Asai, Y., Baucom, J.M., Jani, S.D., Castellanos, Y., Gomez, G., McClintock, J.M., and Hudspeth, A.J. (2010) Transgenic Labeling of Hair Cells in the Zebrafish Acousticolateralis System. Gene expression patterns : GEP. 10(2-3):113-118

Nakamura, Y., Cui, Y., Fernando, C., Kutz, W.E., and Warman, M.L. (2009) Normal growth and development in mice over-expressing the CCN family member WISP3. Journal of cell communication and signaling. 3(2):105-113

Prober, D.A., Zimmerman, S., Myers, B.R., McDermott, B.M. Jr, Kim, S.H., Caron, S., Rihel, J., Solnica-Krezel, L., Julius, D., Hudspeth, A.J., and Schier, A.F. (2008) Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(40):10102-10110

McDermott, B.M., Baucom, J.M., and Hudspeth, A.J. (2007) Analysis and functional evaluation of the hair-cell transcriptome. Proceedings of the National Academy of Sciences of the United States of America. 104(28):11820-11825