ZFIN Lab: Topczewski Lab

ZFIN ID: ZDB-LAB-030911-1

Topczewski Lab

PI/Director:	Topczewski, Jacek
Contact Person:	Topczewski, Jacek
Email:	j-topczewski@northwestern.edu
URL:	http://www.luriechildrens.org/en-us/research/laboratories/Pages/topczewski.aspx
Address:	Department of Pediatrics Northwestern University Feinberg School of Medicine Stanley Manne Children’s Research Institute Ann & Robert H. Lurie Children's Hospital of Chicago Box 204 225 East Chicago Avenue Chicago, IL 60611-2605 USA
Country:	United States
Phone:	Office: (773) 755-6545 Lab: (773) 755-6370
Fax:	(773) 755-6385
Line Designation:	nu

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 18 genomic features

STATEMENT OF RESEARCH INTERESTS

Role of Wnt signaling in zebrafish cartilage morphogenesis.
Function of Glypicans (heparan sulfate proteoglycans) in zebrafish development.

LAB MEMBERS

Anderson, Rebecca Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Yang, H., Luan, Y., Liu, T., Lee, H.J., Fang, L., Wang, Y., Wang, X., Zhang, B., Jin, Q., Ang, K.C., Xing, X., Wang, J., Xu, J., Song, F., Sriranga, I., Khunsriraksakul, C., Salameh, T., Li, D., Choudhary, M.N.K., Topczewski, J., Wang, K., Gerhard, G.S., Hardison, R.C., Wang, T., Cheng, K.C., Yue, F. (2020) A map of cis-regulatory elements and 3D genome structures in zebrafish. Nature. 588(7837):337-343

Oyarbide, U., Shah, A.N., Amaya-Mejia, W., Snyderman, M., Kell, M., Allende, D., Calo, E., Topczewski, J., Corey, S. (2020) Loss of Sbds in zebrafish leads to neutropenia and pancreas and liver atrophy. JCI insight. 5(17)

Anderson, R.A., Schwalbach, K.T., Mui, S.R., LeClair, E.E., Topczewska, J.M., Topczewski, J. (2020) Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Disease models & mechanisms. 13(6):

Baumgartner, E.A., Compton, Z.J., Evans, S., Topczewski, J., LeClair, E.E. (2019) Identification of regulatory elements recapitulating early expression of L-plastin in the zebrafish enveloping layer and embryonic periderm. Gene expression patterns : GEP. 32:53-66

Oyarbide, U., Topczewski, J., Corey, S.J. (2018) Peering through zebrafish to understand inherited bone marrow failure syndromes. Haematologica. 104(1):13-24

Hu, B., Gao, Y., Davies, L., Woo, S., Topczewski, J., Jessen, J.R., Lin, F. (2018) Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition. Development (Cambridge, England). 145(17):

Pogoda, H.M., Riedl-Quinkertz, I., Löhr, H., Waxman, J.S., Dale, R.M., Topczewski, J., Schulte-Merker, S., Hammerschmidt, M. (2018) Direct activation of chordoblasts by retinoic acid is required for segmented centra mineralization during zebrafish spine development. Development (Cambridge, England). 145(9)

Kell, M.J., Riccio, R.E., Baumgartner, E.A., Compton, Z.J., Pecorin, P.J., Mitchell, T.A., Topczewski, J., LeClair, E.E. (2018) Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1). PLoS One. 13:e0190353

Sredni, S.T., Suzuki, M., Yang, J.P., Topczewski, J., Bailey, A.W., Gokirmak, T., Gross, J.N., de Andrade, A., Kondo, A., Piper, D.R., Tomita, T. (2017) A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain. Pediatric blood & cancer. 64(11)

Sisson, B.E., Dale, R.M., Mui, S.R., Topczewska, J.M., Topczewski, J. (2015) A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis. Mechanisms of Development. 138 Pt 3:279-90

Cvjetkovic, N., Maili, L., Weymouth, K.S., Hashmi, S.S., Mulliken, J.B., Topczewski, J., Letra, A., Yuan, Q., Blanton, S.H., Swindell, E.C., Hecht, J.T. (2015) Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family. Molecular genetics & genomic medicine. 3:440-51

Pelliccia, D., Vaz, R., Svalbe, I., Morgan, K.S., Marathe, S., Xiao, X., Assoufid, L., Anderson, R.A., Topczewski, J., Bryson-Richardson, R.J. (2015) Comparison of different numerical treatments for x-ray phase tomography of soft tissue from differential phase projections. Physics in Medicine and Biology. 60:3065-3080

Miller, N., Feng, Z., Edens, B.M., Yang, B., Shi, H., Sze, C.C., Hong, B.T., Su, S.C., Cantu, J.A., Topczewski, J., Crawford, T.O., Ko, C.P., Sumner, C.J., Ma, L., Ma, Y.C. (2015) Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:6038-50

Favelevic, T., Anderson, R., Topczewski, J., Gosain, A.K., Topczewska, J.M. (2014) Abstract 76: Modeling Craniosynostosis in Zebrafish using the Genome Editing Technique CRISPR. Plastic and reconstructive surgery. 133:87

Tomaszewski, J.P., Gart, M.S., Shoela, R.A., Topczewski, J., Topczewska, J.M., Gosain, A.K. (2014) Abstract 52: mutating fibroblast growth factor receptor 1 (fgfr1) in zebrafish to create a new model of craniosynostosis. Plastic and reconstructive surgery. 133:63-4

Gray, R.S., Wilm, T.P., Smith, J., Bagnat, M., Dale, R.M., Topczewski, J., Johnson, S.L., and Solnica-Krezel, L. (2014) Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. Developmental Biology. 386(1):72-85

Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374

Duszynski, R.J., Topczewski, J., and LeClair, E.E. (2013) Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration. Development, growth & differentiation. 55(2):282-300

Cantu, J.A., Flowers, G.P., and Topczewski, J. (2013) Notum homolog plays a novel role in primary motor innervation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(5):2177-2187

Moore, A.C., Mark, T.E., Hogan, A.K., Topczewski, J., and Leclair, E.E. (2012) Peripheral axons of the adult zebrafish maxillary barbel extensively remyelinate during sensory appendage regeneration. The Journal of comparative neurology. 520(18):4184-4203

Flowers, G.P., Topczewska, J.M., and Topczewski, J. (2012) A zebrafish Notum homolog specifically blocks the Wnt/beta-catenin signaling pathway. Development (Cambridge, England). 139(13):2416-2425

Biyashev, D., Veliceasa, D., Topczewski, J., Topczewska, J.M., Mizgirev, I., Vinokour, E., Reddi, A.L., Licht, J.D., Revskoy, S.Y., and Volpert, O.V. (2012) MiR-27b controls venous specification and tip cell fate. Blood. 119(11):2679-2687

Duszynski, R.J., Topczewski, J., and LeClair, E.E. (2011) Simple, Economical Heat-Shock Devices for Zebrafish Housing Racks. Zebrafish. 8(4):211-9

Topczewski, J., Dale, R.M., and Sisson, B.E. (2011) Planar cell polarity signaling in craniofacial development. Organogenesis. 7(4):255-259

Dale, R.M., and Topczewski, J. (2011) Identification of an evolutionarily conserved regulatory element of the zebrafish col2a1a gene. Developmental Biology. 357(2):518-31

Sarmah, S., Barrallo-Gimeno, A., Melville, D.B., Topczewski, J., Solnica-Krezel, L., and Knapik, E.W. (2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. PLoS One. 5(4):e10367

Camarata, T., Krcmery, J., Snyder, D., Park, S., Topczewski, J., and Simon, H.G. (2010) Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation. Developmental Biology. 337(2):233-245

LeClair, E.E., and Topczewski, J. (2010) Development and Regeneration of the Zebrafish Maxillary Barbel: A Novel Study System for Vertebrate Tissue Growth and Repair. PLoS One. 5(1):e8737

LeClair, E.E., and Topczewski, J. (2009) Methods for the study of the zebrafish maxillary barbel. Journal of visualized experiments : JoVE. (33)

LeClair, E.E., Mui, S.R., Huang, A., Topczewska, J.M., and Topczewski, J. (2009) Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(10):2550-2563

Sisson, B.E., and Topczewski, J. (2009) Expression of five frizzleds during zebrafish craniofacial development. Gene expression patterns : GEP. 9(7):520-527

Drerup, C.M., Wiora, H.M., Topczewski, J., and Morris, J.A. (2009) Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development (Cambridge, England). 136(15):2623-2632

Dale, R.M., Sisson, B.E., and Topczewski, J. (2009) The Emerging Role of Wnt/PCP Signaling in Organ Formation. Zebrafish. 6(1):9-14

Postel, R., Vakeel, P., Topczewski, J., Knöll, R., and Bakkers, J. (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Developmental Biology. 318(1):92-101

Carney, T.J., von der Hardt, S., Sonntag, C., Amsterdam, A., Topczewski, J., Hopkins, N., and Hammerschmidt, M. (2007) Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development (Cambridge, England). 134(19):3461-3471

Inbal, A., Topczewski, J., and Solnica-Krezel, L. (2006) Targeted gene expression in the zebrafish prechordal plate. Genesis (New York, N.Y. : 2000). 44(12):584-588

Topczewska, J.M., Postovit, L.M., Margaryan, N.V., Sam, A., Hess, A.R., Wheaton, W.W., Nickoloff, B.J., Topczewski, J., and Hendrix, M.J. (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nature medicine. 12(8):925-932

Lin, F., Sepich, D.S., Chen, S., Topczewski, J., Yin, C., Solnica-Krezel, L., and Hamm, H. (2005) Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. The Journal of cell biology. 169(5):777-787

Cooper, M.S., Szeto, D.P., Sommers-Herivel, G., Topczewski, J., Solnica-Krezel, L., Kang, H.C., Johnson, I., and Kimelman, D. (2005) Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP. Developmental Dynamics : an official publication of the American Association of Anatomists. 232(2):359-368

Ninkovic, J., Tallafuss, A., Leucht, C., Topczewski, J., Tannhäuser, B., Solnica-Krezel, L., and Bally-Cuif, L. (2005) Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development (Cambridge, England). 132(1):75-88

Topczewska, J.M., Topczewski, J., Szostak, A., Solnica-Krezel, L., and Hogan, B.L.M. (2003) Developmentally regulated expression of two members of the Nrarp family in zebrafish. Gene expression patterns : GEP. 3(2):169-171

Lagutin, O.V., Zhu, C.C., Kobayashi, D., Topczewski, J., Shimamura, K., Puelles, L., Russell, H.R., McKinnon, P.J., Solnica-Krezel, L., and Oliver, G. (2003) Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes & Development. 17(3):368-379

Jessen, J.R., Topczewski, J., Bingham, S., Sepich, D.S., Marlow, F., Chandrasekhar, A., and Solnica-Krezel, L. (2002) Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nature cell biology. 4(8):610-615

Solnica-Krezel, L., Marlow, F., Topczewski, J., Jessen, J., and Sepich, D. (2002) Regulation of cell polarity during zebrafish gastrulation. Developmental Biology. 247(2):479

Marlow, F., Topczewski, J., Sepich, D., and Solnica-Krezel, L. (2002) Zebrafish rho kinase 2 acts downstream of wnt11 to mediate cell polarity and effective convergence and extension movements. Current biology : CB. 12(11):876-884

Topczewska, J.M., Topczewski, J., Shostak, A., Kume, T., Solnica-Krezel, L., and Hogan, B.L. (2001) The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. Genes & Development. 15(18):2483-2493

Topczewski, J., Sepich, D.S., Myers, D.C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J., and Solnica-Krezel, L. (2001) The zebrafish glypican Knypek controls cell polarity during gastrulation movements of convergent extension. Developmental Cell. 1(2):251-264

Solnica-Krezel, L., Topczewski, J., Sepich, D., Myers, D., Marlow, F., and Jessen, J. (2001) Genetic control of convergent extension movements during zebrafish gastrulation. Developmental Biology. 235(1):175 (#17)

Topczewska, J.M., Topczewski, J., Solnica-Krezel, L., and Hogan, B.L. (2001) Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. Mechanisms of Development. 100(2):343-347

Gonzalez, E.M., Fekany-Lee, K., Carmany-Rampey, A., Erter, C., Topczewski, J., Wright, C.V.E., and Solnica-Krezel, L. (2000) Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino. Genes & Development. 14(24):3087-3092

Sepich, D.S., Myers, D.C., Short, R., Topczewski, J., Marlow, F., and Solnica-Krezel, L. (2000) Role of the zebrafish trilobite locus in gastrulation movements of convergence and extension. Genesis (New York, N.Y. : 2000). 27(4):159-173

Fekany, K., Yamanaka, Y., Leung, T., Sirotkin, H.I., Topczewski, J., Gates, M.A., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A.F., Driever, W., Hirano, T., Talbot, W.S., and Solnica-Krezel, L. (1999) The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development (Cambridge, England). 126:1427-1438

Topczewski, J. and Solnica-Krezel, L. (1999) Cytoskeletal dynamics of the zebrafish embryo.. Methods in cell biology. 59:205-226