FIGURE SUMMARY
Title

Two Small Peptides from Buthus martensii Hydrolysates Exhibit Antitumor Activity Through Inhibition of TNF-α-Mediated Signal Transduction Pathways

Authors
Zhu, M., Zhang, S., Tang, J., Hou, H., Wang, L., Lin, H., Zhang, X., Jin, M.
Source
Full text @ Life (Basel)
Figure 1

Identification of the small peptides AK and GK using the Mascot search engine and MS/MS analyses.
Figure 2

KEGG analysis (A) and core target prediction (B) for AK and GK. Targets were classified based on the “Degree” score: the green triangle nodes (Degree ≥ 29) and the red circular nodes (9 ≤ Degree < 29).
Figure 3

Molecular docking analysis of AK (A) and GK (B). Docked poses (a) and H-bonding interactions (b) between the peptides and macromolecules.
Figure 4

Effects of AK and GK on the inflammatory microenvironment. (* p < 0.05, ** p < 0.01 versus the model group). The white dotted box represented the area where inflammatory cells were observed. The yellow arrows indicated the aggregation of inflammatory cells.
Figure 5

Effects of AK (A) and GK (B) on total and phosphorylated EGFR and STAT3 protein expression levels. (* p < 0.05, ** p < 0.01 versus the TNF-α group).
Figure 6

Effects of AK (A) and GK (B) on c-myc, p53, and PTEN protein expression levels. (* p < 0.05, ** p < 0.01 versus the TNF-α group).
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Life (Basel)
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