FIGURE SUMMARY
Title

Correction: A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration

Authors
Liang, S., Zhou, Y., Chang, Y., Li, J., Zhang, M., Gao, P., Li, Q., Yu, H., Kawakami, K., Ma, J., Zhang, R.
Source
Full text @ Cell. Mol. Life Sci.
Fig. 7

csrp3 overexpression relieves the inhibitory effects of multiple signaling blockage on zebrafish heart regeneration. A, B Comparative analysis of the expression changes of GFP in ablated +/218A hearts and endogenous csrp3 in ablated wild-type hearts after inhibiting blood flow (tricaine), Notch (DAPT), and ErbB (AG1478) signaling. Scale bars, 20 μm. C Fluorescence pattern of Tg(cmcl2:Csrp3-EGFP) at 4 dpf. Scale bars, 20 μm. D Confocal images showed that Csrp3 overexpression (OE) ameliorated the impairment of heart regeneration resulting from inhibiting blood flow (tricaine), Notch (DAPT), and ErbB (AG1478) signaling. Scale bars, 20 μm. E Quantification of the regeneration ratio of ablated wild-type and Csrp3 overexpressed larvae after treatment with indicated inhibitors at 4 dpa/7 dpf. N = 481, 548, 487, 411, 689, 524, 312, 328, respectively. Data are presented as mean ± SD, Student’s t-test, **, p < 0. 01, ***, P < 0.001, ****, P < 0.0001

Fig. S6

The effects of pharmacological blockage of multiple signaling pathways on csrp3 expression during zebrafish heart regeneration. A Schematic timeline diagram of the pharmacological experiments. B, C Fluorescence images and WISH showed the expression changes of GFP in +/218A hearts and endogenous csrp3 in wild-type hearts treated with Wnt inhibitor cardiomogen-1 (Car), BMP inhibitors dorsomorphin (DM) and LDN193189 (LDN), and mTOR inhibitor rapamycin (Rapa). Scale bars, 20 μm

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell. Mol. Life Sci.
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