FIGURE SUMMARY
Title

Synthesis and molecular docking studies of new aryl imeglimin derivatives as a potent antidiabetic agent in a diabetic zebrafish model

Authors
Khodakhah, A., Mohammadi, H., Abdoli, S., Zarei, I., Palimi, M., Ekhtiari, Z., Talebi, M., Biglar, M., Khorramizadeh, M.R., Amanlou, M.
Source
Full text @ Sci. Rep.
Figure 1

Chemical structure of some metformin derivatives and designed compounds.
Figure 2

Ligand binding interactions in the active site of GSK-3β, (A) 3b, (B) 3e, (C) 3g. and 2D display of the interactions of compounds D) 3b, (E) 3e, (F) 3g.
Figure 3

Ligand binding interactions in the active site of SIRT1, (A) 3b, (B) 3e, (C) 3g. and 2D display of the interactions of compounds (D) 3b, (E) 3e, (F) 3g.
Figure 4

Superimpose position of compounds 3b (green), 3e (red), 3g (blue) and imeglimin (yellow) in the active site of (A) GSK-3β and (B) SIRT1.
Scheme 1

General Scheme for the synthesis of imeglimin derivatives 3(a–j).
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.
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