FIGURE 1

Effect of C. officinalis extracts on the loss of DA neurons in the MPTP‐induced zebrafish model. (a) Control group, (b) MPTP group, (c) Positive group, (d) MPTP + 2.5 μg/mL extract, (e) MPTP + 5 μg/mL extract and (f) MPTP + 10 μg/mL extract. DA neurons are indicated by the red brackets; scale bar, 100 μm.
FIGURE 2

Compounds identified in C. officinalis flower extracts using LC‐Q/TOF‐MS/MS. (1) chlorogenic acid, (2) 3,4‐dicaffeoylquinic acid, (3) rutin, (4) isorhamnetin 3‐O‐glucoside and (5) calenduloside E.
FIGURE 3

Molecular docking of (a) 3,4‐dicaffeoylquinic acid, (b) isorhamnetin 3‐O‐glucoside and (c) calenduloside E with Hsp90α protein.
FIGURE 4

Total and phosphorylated ERK in the SH‐SY5Y cells. Cells without a drug treatment were used as the control group (relative ratio values were set to 1). *p < .05, **p < .01 versus the Model group.
FIGURE 5

Total and phosphorylated PI3K in the SH‐SY5Y cells. Cells without a drug treatment were used as the control group (relative ratio values were set to 1). *p < .05, **p < .01 versus the Model group.
Acknowledgments
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