FIGURE SUMMARY
Title

Oxytocin protective effects on zebrafish larvae models of autism-like spectrum disorder

Authors
Rahmati-Holasoo, H., Salek Maghsoudi, A., Akbarzade, M., Gholami, M., Shadboorestan, A., Vakhshiteh, F., Armandeh, M., Hassani, S.
Source
Full text @ Iran J Basic Med Sci
Figure 1

An overview of the experimental design and endpoints measured in zebrafish larvae exposed to sodium valproate and oxytocin during the experimental period
Figure 2

Confocal microscope images of larval brains taken at 20x and 40x magnifications in control groups (A and B) and FITC-conjugated oxytocin treatments (C and D). Green spots are the areas that oxytocin has reached
Figure 3

Protective effect of oxytocin in improving social behavior indices in terms of crossed times/min (A) and % of time spent in the light (B) on the Light/Dark background preference behavior. The values are displayed as mean ± SD (n=3). (a) P<0.05, compared with the positive control group. (b) P<0.05 and (bb) P<0.01 compared with control
Figure 4

Protective effect of oxytocin in improving social behavior indices in terms of NND (A) and IID (B) on shoaling behavior. The values are displayed as mean ± SD (n=3). (a) P<0.05, compared with the positive control group. (bbb) P<0.001 compared with control
Figure 5

Protective effect of oxytocin in improving social behavior indices in terms of the number of attacks (A) and % of time at mirror (B) on Mirror attack behavior. The values are displayed as mean ± SD (n=3). (a) P<0.05, (aa) P<0.01 compared with the positive control group, and (bbb) P<0.001 compared with control
Figure 6

Protective effect of oxytocin in improving social behavior indices in terms of number of contacts/min (A) and % of time in contact (B) on Social contacts test. Values are displayed as mean ± SD (n=3). (a) P<0.05, (aa) P<0.01 compared with the positive control group, and (bbb) P<0.001 compared with control
Figure 7

Effect of oxytocin exposure on the expression of genes involved in autism-like behavior in zebrafish larvae. shank3a (A), shank3b (B), and oxytocin receptor (C). The values are provided as mean ± SD (n=3). *P<0.05, **P<0.01, and ***P<0.001 compared with positive control group. #P<0.05, ##P<0.01, and ###P<0.001 compared with control, respectively
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Iran J Basic Med Sci
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