FIGURE SUMMARY
Title

Inhibitory Effect of Morin Against Candida albicans Pathogenicity and Virulence Factor Production: An in vitro and in vivo Approaches

Authors
Abirami, G., Alexpandi, R., Durgadevi, R., Kannappan, A., Veera Ravi, A.
Source
Full text @ Front Microbiol

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Microscopic analysis of C. albicans biofilms in the absence and presence of morin at MBIC. (A) Light microscope. (B) Confocal laser scanning microscope. (C) Scaning electron microscope analysis.

Effect of morin on filamentous morphology. Hyphal morphology was significantly reduced at MBIC concentration (at MBIC).

(A) Activity of morin against C. albicans in an agar invasion assay. (B) Effect of morin on C. albicans protease production at the increasing concentration (37.5, 75, and 150μg/ml). Data are presented as means ± SD. *Indicates the statistical significance (p < 0.05). (C) Effect of morin (at MBIC) on C. albicans phospholipase production.

(A) Effect of morin (at MBIC) on C. albicans catalase production. (B) Quantitative analysis of the catalase inhibitory activity of morin (at MBIC).

Docking analysis shows the binding pattern and amino acid interactions of morin (−6.1 kcal/mol) with Hwp1 receptor in C. albicans for possible inhibition of adhesion as well as biofilm formation.

Histopathology analysis of the Gills (A), Intestine (B), and Kidney (C) sections of uninfected control, C. albicans infected control and morin treated zebrafishes.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Microbiol