FIGURE SUMMARY
Title

Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish

Authors
den Broeder, M.J., Ballangby, J., Kamminga, L.M., Aleström, P., Legler, J., Lindeman, L.C., Kamstra, J.H.
Source
Full text @ Epigenetics Chromatin
Fig. 1

Phenotypic effects of PF-06726304 acetate (Ezh2i). a Structural formula of PF-06726304 acetate (source: http://www.sigmaaldrich.com). b Developmental exposure to a concentration range of Ezh2i at 1, 2 and 5 days post-fertilization (dpf). c Concentration–response curve of Ezh2i at 5 dpf. d Length measurements of larvae following exposure to Ezh2i at 5 dpf. Error bars indicate standard deviation (SD)
Fig. 2

Lipid accumulation after exposure to PF-06726304 acetate (Ezh2i) and tributyltin (TBT). a Experimental design. Embryos are either exposed to Ezh2i or TBT in a short or long exposure window. b Representative images for ORO staining with low, medium or high staining levels. c Scatter plot of ORO staining following the different treatments. Average and error bars (95% CI) indicated in black (****padj-value < 0.0001)
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Epigenetics Chromatin
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