FIGURE SUMMARY
- Title
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The Impact of the Epigenetic Cancer Drug Azacitidine on Host Immunity: The Role of Myelosuppression, Iron Overload and tp53 Mutations in a Zebrafish Model
- Authors
- Wang, S.C., Wu, C.T., Wu, D.Y., Chen, C.G., Chang, K.M., Chang, C.C.
- Source
- Full text @ Cancers
Prolonged survival to bacterial infection in azacitidine-treated zebrafish carrying the tp53M214K mutation. ( A) Micrographs of an over 8-month-old tp53M214K mutant zebrafish showing zMPNST in its right eye. The Kaplan–Meier survival curve of mock- or azacitidine (Aza)-pretreated WT or tp53M214K mutant zebrafish challenged with ( B) E. coli (107 CFU), ( C) V. vulnificus (105 CFU) or ( D) S. iniae (103 CFU), n = 30 for each group, analyzed by the Kaplan–Meier log rank test. The Day-5 ( E) and Day-10 ( F) survival rates are shown. Results are mean ± SD of three independent experiments. * p < 0.05, ns, not significant, by Student’s t test. |
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Full text @ Cancers