FIGURE SUMMARY
- Title
-
Zebrafish Xenograft Model of Human Lung Cancer for Evaluating Osimertinib Resistance
- Authors
- Li, X.Y., Huang, L.T., Wu, J.Q., He, M.F., Zhu, S.H., Zhan, P., Lv, T.F., Song, Y.
- Source
- Full text @ Biomed Res. Int.
Lung cancer cells survive in zebrafish larvae and induce angiogenesis. Zebrafish are labeled as fli-eGFP; the tumor cells were labeled with red fluorescence. (a) PC9 xenograft zebrafish treated with Osimertinib at 24 hpf and observed at 3 dpt. (b) Quantitative analysis of the PC9 cells proliferation with/without Osimertinib treatment at 3 dpt. (c) PC9-GR xenograft zebrafish treated with Osimertinib at 24 hpf and observed at 3 dpt. (d) Quantitative analysis of the PC9-GR cells proliferation with/without Osimertinib treatment at 3 dpt. Hpf: hours postfertilization; dpt: days posttreatment. PHENOTYPE:
|
Osimertinib inhibits the growth of zebrafish xenografts produced by lung cancer cells. Zebrafish are labeled as fli-eGFP; the tumor cells were labeled with red fluorescence. (a) H1975 xenograft zebrafish treated with Osimertinib at 24 hpf and observed at 3 dpt. (b) Quantitative analysis of the H1975 cells proliferation with/without Osimertinib treatment at 3 dpt. (c) H1975-OR xenograft zebrafish treated with Osimertinib at 24 hpf and observed at 3 dpt. (d) Quantitative analysis of the H1975-OR cells proliferation with/without Osimertinib treatment at 3 dpt. Hpf: hours postfertilization; dpt: days posttreatment. PHENOTYPE:
|
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Biomed Res. Int.