- Title
-
Panax ginseng (Korea Red Ginseng) repairs diabetic sensorineural damage through promotion of the nerve growth factor pathway in diabetic zebrafish
- Authors
- Nam, Y.H., Moon, H.W., Lee, Y.R., Kim, E.Y., Rodriguez, I., Jeong, S.Y., Castaņeda, R., Park, J.H., Choung, S.Y., Hong, B.N., Kang, T.H.
- Source
- Full text @ J Ginseng Res
(A) Scheme of experiment. (B) Lateral line for zebrafish. (C) Number of trunk neuromasts of alloxan dose-dependently damaged zebrafish. (D) Fluorescent microscopic image of trunk neuromast following treatment with 0.1 YO-PRO (*p < 0.05, **p < 0.01, ***p < 0.001; compared to normal (NOR) zebrafish). |
Scanning electron microscopy (SEM) images of representative neuromasts in zebrafish larva. Scale bar = 3 μm. RG, red ginseng. |
Measure of resting membrane potential on an L1 neuromast. (A) Lateral mounting of zebrafish shows the location of the microelectrode in the L1 neuromast. (B) Value of resting membrane potential. (C) Image of an L1 neuromast (###p < 0.001; compared to normal, *p < 0.05; compared to alloxan treatment). L1, lateral neuromast 1; RG, red ginseng. |
Effect of RG on pancreatic islet. (A) Pancreatic islet size by RG. (B) Pancreatic islet image of each group. (C) Relative fluorescence intensity of pancreatic β-cells by RG. (D) Pancreatic β-cell image of each group (###p < 0.001; compared to normal, *p < 0.05; compared to alloxan treatment, *p < 0.05, **p < 0.01). RG, red ginseng. |