FIGURE SUMMARY
Title

Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression

Authors
Kabakci, Z., Käppeli, S., Cantù, C., Jensen, L.D., König, C., Toggweiler, J., Gentili, C., Ribaudo, G., Zagotto, G., Basler, K., Pinna, L.A., Cozza, G., Ferrari, S.
Source
Full text @ Sci. Rep.
Fig. 6

CDC25 inhibitors block the growth of K-Ras-dependent intestinal organoids. (A) Organoids reproducing duodenal crypts and derived from Apc/K-Ras mouse small intestine (left) were grown in the presence of UPD-176 (right). Phase contrast stills were obtained at 48 h of treatment. (B) Confocal immunofluorescence microscopy of Apc/K-Ras organoids treated as in A and stained for proliferation (β-catenin) or differentiation (lysozyme) markers. DNA was stained with DAPI. (C) qRT-PCR on cDNA obtained from control- and UPD-176-treated organoids was conducted using primers to the indicated markers.
Fig. 7

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PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Day 5
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.
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