- Title
-
Murrangatin suppresses angiogenesis induced by tumor cell-derived media and inhibits AKT activation in zebrafish and endothelial cells
- Authors
- Long, W., Wang, M., Luo, X., Huang, G., Chen, J.
- Source
- Full text @ Drug Des Devel Ther
Effects of murrangatin on morphological changes of zebrafish embryo. Morphological changes are not different among different groups. Representative photographs of the morphological changes of the embryos treated with different concentrations of the murrangatin are shown. Experiments were performed in triplicate. |
Murrangatin inhibited angiogenesis of SIVs in vivo. (A) Fluorescence images show the SIV morphology of 72-hpf TG (fli1: EGFP) zebrafish embryos treated with DMSO or different concentrations of murrangatin. (B) Quantification of the SIV length in 72 hpf embryos in the vehicle control group and murrangatin-treated groups. Data are expressed as mean ± SEM from three independent experiments (*p < 0.01 vs control; one-way ANOVA). |