- Title
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SOX5 predicts poor prognosis in lung adenocarcinoma and promotes tumor metastasis through epithelial-mesenchymal transition
- Authors
- Chen, X., Fu, Y., Xu, H., Teng, P., Xie, Q., Zhang, Y., Yan, C., Xu, Y., Li, C., Zhou, J., Ni, Y., Li, W.
- Source
- Full text @ Oncotarget
Silencing SOX5 reducesH1299 cell proliferation and metastasis in vivo. (A) Zebrafish cancer xenograft assay of H1299 cells with silenced SOX5. Arrows indicate metastatic tumor cells. (B) The integrated fluorescence intensity of tumors in the H1299-shSOX5 group compared with the H1299-NC group,**p < 0.01,***p < 0.001. (C) The metastasis inhibition of SOX5 knockdown. Arrows indicate metastatic tumor cells. (D) The cumulative distance of cell migration in the H1299-shSOX5 group compared with the H1299-NC group, **p < 0.01. (E) The schematic diagram of data collection and analysis in the zebrafish cancer xenograft model. |