- Title
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Inadequate Dietary Phosphorus Levels Cause Skeletal Anomalies and Alter Osteocalcin Gene Expression in Zebrafish
- Authors
- Costa, J.M., Sartori, M.M.P., Nascimento, N.F.D., Kadri, S.M., Ribolla, P.E.M., Pinhal, D., Pezzato, L.E.
- Source
- Full text @ Int. J. Mol. Sci.
Deficient dietary phosphorus intake impairs zebrafish (Danio rerio) skeletal development. Vertebral and spinal anomalies are shown in zebrafish fed with T1–T6 levels of phosphorus in the diet (T1 = 0.35%; T2 = 0.65%; T3 = 0.95%; T4 = 1.25%; T5 = 1.55%; T6 = 1.85%). (A) Partial fusion in neural and hemal spines in T2 fishes; (B) Absence of neural and hemal spine fusions in T1 fishes; (C) Absence of parallelism between neural and hemal spines in T2 fishes; (D–F) Caudal vertebral and spinal anomalies; (D) Normal vertebral column in T5 fishes; (E) Deformed vertebral column at the caudal fin region (the dotted line represents the estimated normality) in T1 fishes; and (F) anchylosis in T1 fishes. N and H arrows point to the neural and hemal spines, respectively. Scale bar: 500 μm. PHENOTYPE:
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Skeletal anomalies of zebrafish (Danio rerio) fed with low dietary phosphorus levels. (A) Lordosis and (B) scoliosis anomalies in T1 fish. (A,B) The dotted lines represent the estimated normal vertebral column curvatures. Scale bar: 500 μm. PHENOTYPE:
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Craniofacial anomaly in zebrafish (Danio rerio) fed diets with different phosphorus levels (T1–T6; T1 = 0.35%; T2 = 0.65%; T3 = 0.95%; T4 = 1.25%; T5 = 1.55%; T6 = 1.85%). (A) Normal head (T5 fish); (B) lower mandible larger than upper mandible (undershot) (T1 fish). Scale bar: 500 μm. PHENOTYPE:
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ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. PHENOTYPE:
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ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. EXPRESSION / LABELING:
PHENOTYPE:
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