FIGURE SUMMARY
Title

Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays

Authors
Shen, M., Tian, S., Pan, P., Sun, H., Li, D., Li, Y., Zhou, H., Li, C., Lee, S.M., Hou, T.
Source
Full text @ Sci. Rep.
Fig. 9

The protective effects of TS-15 and TS-40 against atorvastatin-induced cerebral hemorrhage in zebrafish.

(A,a and Aa) the embryos treated with 0.2% DMSO served as the normal control group; (B,b and Bb; C,c and Cc; D,d and Dd; E,e and Ee) the embryos were pretreated with either 0.2% DMSO, Y27632 (10?mM), TS-15 (20?mM) or TS-40 (20?mM) for 2.0?hours and replaced with 1?mM atorvastatin for 24?hours. Homozygous double transgenic zebrafish, the red fluorescence was the Tg (gata1: dsRed) sd2 (A?E), the green fluorescence was Tg (fli1a: EGFP) y1 (a?e), and the third column was the overlapping photos of the first two columns (Aa, Bb, Cc, Dd and Ee). The arrows indicated the erythrocyte accumulation in cerebral hemorrhage region in zebrafish head.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.
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