FIGURE SUMMARY
Title

E2F4 Promotes Neuronal Regeneration and Functional Recovery after Spinal Cord Injury in Zebrafish

Authors
Sasagawa, S., Nishimura, Y., Hayakawa, Y., Murakami, S., Ashikawa, Y., Yuge, M., Okabe, S., Kawaguchi, K., Kawase, R., Tanaka, T.
Source
Full text @ Front Pharmacol
Fig. 3

Larval zebrafish SCI model used in this study. At 5 dpf, the spinal cords of zebrafish were injured using a device for microdissection (Movie S1). At 0, 1, 2, and 3 dpi, the locomotive behavior of zebrafish was analyzed (Figure 4, Movies S2, S3). At 3 dpi, in vivo imaging of the spinal cord was performed (Figure 5). A representative SCI in zebrafish is indicated by the red arrow.
Fig. 5

Neuronal regeneration after SCI was impaired in zebrafish treated with E2F4 inhibitor. (A) Representative in vivo imaging of Tg(eno2: Cerulean) zebrafish. (B) Representative in vivo imaging of Tg(eno2: Cerulean) zebrafish with SCI at 3 dpi treated with or without HLM006474. (C) The Cerulean area in the ROI was quantified and compared between zebrafish with SCI treated with or without HLM006474. N = 24 and 22 for zebrafish without and with HLM006474, respectively. #p < 0.05 compared to SCI without HLM006474.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol
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