FIGURE SUMMARY
Title

Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity

Authors
Nishimura, Y., Sasagawa, S., Ariyoshi, M., Ichikawa, S., Shimada, Y., Kawaguchi, K., Kawase, R., Yamamoto, R., Uehara, T., Yanai, T., Takata, R., Tanaka, T.
Source
Full text @ Front Pharmacol
Fig. 6

Inhibition of EP300 reduces the adiposity in larval zebrafish. (A) Network between EP300 and the target genes identified iRegulon in adipose tissues of DIO zebrafish and obese humans with and without RES and CR. (B) Changes in the visceral adiposity of zebrafish treated with RES and/or C646. The area stained with Nile Red is shown compared with that of control (arbitrarily defined as 100%). Values are the means ± SEM. N = 10–12/group. #p < 0.05 vs control.
Fig. S1

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Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol
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