- Title
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Alzheimer's-Related Peptide Amyloid-beta Plays a Conserved Role in Angiogenesis
- Authors
- Cameron, D.J., Galvin, C., Alkam, T., Sidhu, H., Ellison, J., Luna, S., and Ethell, D.W.
- Source
- Full text @ PLoS One
Morphology and vascular imaging of GFP-expressing zebrafish embryos. A) Projection image of a 3 dpf embryo using images captured by confocal microscopy. B, C) Comparable projection of a 3 dpf embryo treated with Aβ (25 μg/mL) and Rev Aβ, respectively. Boxes indicate the region analyzed for CtA branching, shown in detail in figure 4. Scale bar = 100 μm, for A–C. EXPRESSION / LABELING:
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Comparison of cerebrovascular structures in control zebrafish embryos at 3–7 dpf. Embryos expressed GFP in endothelial cells and images were captured with a confocal microscope. EXPRESSION / LABELING:
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Gamma-secretase inhibitor effects on morphology. A) Dorsal view of 4 dpf embryos: control – top, Aβ [25] treated – middle, and GSI treated – bottom. B, C) Lateral view of control and GSI- treated 4 dpf embryos, respectively. |