Person
Chatani, Masahiro
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Biography and Research Interest
My motivation for science began with the question of how organisms have adapted to the Earth's environment. Using medaka fish as a model animal, I have focused on bone-dissolving cells called osteoclasts to study bone development and regeneration, and also participated in the projects using the International Space Station to study the effects of gravity. From July 2021, as a visiting scientist at the Stainier Lab, I am studying the origin of the circulatory system using medaka fish.
Non-Zebrafish Publications
MEDAKA PUBLICATIONS:
*Furukawa S, *Chatani M, *Higashitani A, Higashibata A, Kawano F, Nikawa T, Numaga-Tomita T, Ogura T, Sato F, Sehara-Fujisawa A, Shinohara M, Shimazu T, Takahashi S, Watanabe-Takano H. Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth. NPJ MICROGRAVITY 7(1) 2021 DOI: 10.1038/s41526-021-00145-9
Takahashi N, Takami M, *Chatani M. Investigation of osteogenesis changes in medaka larvae reared in normal gravity, simulated-microgravity and hypergravity environments. Biological Sciences in Space 35:24-31, 2021. DOI: 10.2187/bss.35.24
Dodo Y, *Chatani M, Azetsu Y, Hosonuma M, Karakawa A, Sakai N, Negishi-Koga T, Tsuji M, Inagaki K, Kiuchi Y, Takami M. Myelination during fracture healing in vivo in myelin protein zero (p0) transgenic medaka line. Bone, 133, 115225, 2020. DOI: 10.1016/j.bone.2020.115225
*Chatani M, Mitsuhashi A, Dodo Y, Sakai N, and Takami M. Hypergravity induces vertebrae and otolith deformation in medaka fish. Biological Sciences in Space, Vol.33, 12-17, 2019. doi: 10.2187/bss.33.12
Azetsu Y, *Chatani M, Dodo Y, Karakawa A, Sakai N, Negishi-Koga T, Takami M. Treatment with synthetic glucocorticoid impairs bone metabolism, as revealed by in vivo imaging of osteoblasts and osteoclasts in medaka fish. Biomedicine & Pharmacotherapy, 118, 109101, 2019. doi: 10.1016/j.biopha.2019.109101
Chatani M, Morimoto H, Takeyama K, Mantoku A, Tanigawa N, Kubota K, Suzuki H, Uchida S, Tanigaki F, Shirakawa M, Gusev O, Sychev V, Takano Y, Itoh T and *Kudo A (2016) Acute transcriptional up-regulation specific to osteoblasts/osteoclasts in medaka fish immediately after exposure to microgravity. Scientific Reports, 6, 39545, p 1-14
Mantoku A, Chatani M, Aono K, Inohaya K, *Kudo A (2016) Osteoblast and osteoclast behaviors in the turnover of attachment bones during medaka tooth replacement. Developmental Biology, 409, p 370-81
Takeyama K, Chatani M, Inohaya K, *Kudo A (2016) TGFβ-2 signaling is essential for osteoblast migration and differentiation during fracture healing in medaka fish. Bone, 86, p 68-78
Murata Y, Yasuda T, Watanabe-Asaka T, Oda S, Mantoku A, Takeyama K, Chatani M, Kudo A, Uchida S, Suzuki H, Tanigaki K, Shirakawa M, Fujisawa K, Hamamoto Y, Terai S, *Mitani H (2015) Histological and transcriptomic analysis of adult Japanese medaka sampled onboard the international space station. PLOS ONE, 10, e0138799, p 1-16
Chatani M, Mantoku A, Takeyama K, Abduweli D, Sugamori Y, Aoki K, Ohya K, Suzuki H, Uchida S, Sakimura T, Kono Y, Tanigaki F, Shirakawa M, Takano Y and *Kudo A (2015) Microgravity promotes osteoclast activity in medaka fish reared at the international space station. Scientific Reports, 5, 14172, p 1-13
Takeyama K, Chatani M, Takano Y, *Kudo A (2014) In-vivo imaging of the fracture healing in medaka revealed two types of osteoclasts before and after the callus formation by osteoblasts. Developmental Biology, 394, p 292-304
Nemoto Y, Chatani M, Inohaya K, Hiraki Y, *Kudo A (2008) Expression of marker genes during otoconial development in medaka. Gene Expression Patterns, 8, p 92-95