ZFIN ID: ZDB-PERS-001003-5
Hong, Jiann-Ruey
Email: jrhong@mail.ncku.edu.tw
URL:
Affiliation: Jen-Leih Wu Lab
Address: Laboratory of Marine Molecular Biology and Biotechnology Institute of Zoology Academia Sinica Nankang Taipei, 11529 Taiwan
Country: Taiwan
Phone: 886-6-200-3082
Fax: 886-6-276-6505
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
PERSONAL INFORMATION:

Name: Jiann-Ruey Hong

Date of Birth: March 30, 1961

Place of Birth: Kaushon County

Marital Status: Married (three children)

Address: Number 128, Section 2, Academia Road, Nankang, Taipei 115,
Taiwan, R.O.C.

Telephone: 88-2-2789-9534(F), 88-2-2651-2741(H)

E-mail: JRHong@gate.sinica.edu.tw

EDUCATION:

B.S: September 1983 - June 1986, Department of Husbandry, Chinese Culture University, Taipei, Taiwan, R.O.C.

M.S: September 1989 - June 1991, Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan, R.O.C.

Ph.D: September 1994 - June 1999, Institute of Life Science, National Defense Medical Center, Taipei, Taiwan, R.O.C.

Postdoctoral fellow: July 1999 - present, Institute of Zoology, Academia Sinica, Nankang, Taipei, Taiwan, R.O.C.

RESEARCH TOPICS:

M.S. Thesis: 'Preparation of Monoclonal Antibodies Against Human
Red Blood Cell Spectrin.'

Ph.D. Dissertation: 'Induction and Molecular Regulation of Host Cell Apoptosis by Infectious Pancreatic Necrosis Virus Infection.'

Postdoctoral Fellow: (1). Studies on a novel Bcl-2 family number VP5 that play an anti-apoptosis function in IPNV early replication cycle and up-regulate the survival factor Mcl-1. (2). Focus on the viral death gene VP3 that triggered the cell death in late replication. (3). In ViVo system: assayed the death gene function in zebrafish by microinjection.

AWARDS:

Awarded traveling expenses from Academia Sinica to Third
Programmed Cell Death Symposium, September 29 - October 3, 1999, Cold Spring Harbar Laboratory, United States of America.

Awarded traveling expenses from National Science Council to 18th International Congress of Biochemistry and Molecular Biology, July 16-20, 2000, United Kingdom.

INVITING PRESENTATION:

October 5, 1999. Biotechnology Center, University of Connecticut. 'Apoptosis induced by Infectious Pancreatic Necrosis Virus infection.'

October 7, 1999. Department of Microbiology, Oregon University. 'A New Apoptosis system by Fish Birnavirus.

PUBLICATIONS:

(A) SCI Journals:

1. J. C. Hong., T. H. Hong., J. G. Chang and T. H. Chang. 1993.
Production and Characterization of Monoclonal Antibodies Against and Spectrin Subunits. J. Formos. Med. Assoc. 92(1), 61-67. .

2. J. L Wu., J. R. Hong, C. Y. Chang., C. F. Hui., C. F. Liao
and Y. L. Hsu. 1998. Involvement of Serine Proteinase in Infectious Pancreatic Necrosis Virus Capsid Protein Maturation and NS Proteinase Cleavace in CHSE-214 Cells. J. of Fish Diseases.21:215-220.

3. J. R. Hong., T. L. Lin, Y. L. Hsu and J. L. Wu. 1998.
Apoptosis procedes necrosis of fish cell line with infectious pancreatic necrosis virus infection. Virology. 250:76-84.

4. J. R. Hong., T. L. Lin., Y. L. Hsu and J. L. Wu. 1998.
Induction of apoptosis and secondary necrosis by infectious pancreatic necrosis virus in fish embryonic cells. Journal of Fish Disease.21, 463-467.

5. J. R. Hong., Y. L. Hsu and J. L. Wu. 1999. Infectious
pancreatic necrosis virus induce apoptosis due to down-regulation the surviral factor MCL-1 in fish cell line. Virus Research 63, 75-83.

6. J. R. Hong., T. L. Lin., J. Y. Yang., Y. L. Hsu and J. L. Wu.
1999. Non-typical apoptotic morphological change in infectious pancreatic necrosis virus induced apoptosis when imaged by green fluorescent protein. Journal of Virology 73, 5056-5063.

(B) Conference, Poster, Abstract:

1. J. C. Hong., T. H. Hong., J. G. Chang and T. H. Chang. 1991.
Preparation of Monoclonal Antibodies against Spectrin of Human Erythrocytes.

2. Hong, J. C., C. Y. Chang. and J. L. Wu. 1994. Serine
Proteinase Involved in Capsid Protein(VP2) Maturation of Infectious Pancreatic Necrosis Virus (IPNV) in CHSE-214. The Ninth Joint Annual Conference of Biomedical Sciences, Taipei, p69.

3.

4. Wu, J.L., J.R. Hong, C.Y. Chang, C.F. Liao and Y.L. Hsu.
1995. Involvement of serine proteinase in infectious pancreatic necrosis virus capsid protein maturation.23rd Meeting of the Federation of the European Biochemical Societies,Basel, Switzerland, August 13-18, Abstract.

5.

6. J. R. Hong., T. L. Lin., Y. L. Hsu. and J. L. Wu. 1997. The
studies of the apoptosis of CHSE cells induced by IPNV infection. Symposium of the Fisheries Society of Taiwan. pp.126.

7. J. R. Hong., Y. L. Hsu and J. L. Wu. 1998. Infectious
pancreatic necrosis virus induce apoptosis due to down-regulation the surviral factor MCL-1 in fish cell line. 4th International Symposium on Viruses of Lower Vertebrates. 12-15 MAY. UK.

8. J. R. Hong., Y. L. Hsu. and J. L. Wu. 1998. Infectious
pancreatic necrosis virus induce apoptosis which correlate to down-regulation the survival factor MVL-1 expression in fish cell line. The 32nd Annual Meeting of The Chinese Society of Microbiology. Taiwan, R.O.C. pp.CSW-97

9. J. R. Hong, Y. L. Hsu and J. L. Wu. 1999. Cloning and
Functional Analysis of Infectious Pancreatic Necrosis Virus VP5: A novel Bcl-2 family member with Regulation Viral Expression and Anti-cell Death Activity. Third programmed cell death symposium . USA. September 29-October 3, 1999. pp. 93.

10. W. L. Wang, J. R. Hong, C. F. Weng and J. L. Wu. Hammerhead ribozymes of VP5 gene on the inhibition of infectious pancreatic virus (IPNV) expression. The fifteenth joint annual conference of biomedical sciences. Taiwan. March 25-26, 2000. pp. 148.

11. C. J. Tai, J. R. Hong and J. L. Wu. Inhibition of IPNV-induced apoptosis by its VP3 antisense RNA expression in fish cell line. The fifteenth joint annual conference of biomedical sciences, March 25-26, 2000. pp. 148.

12. Jiann-Ruey Hong and Jen-Leih Wu. A novel Bcl-2 family member from aquabirnavirus that with anti-apoptotic death function but without transmembrane domain. 18th international congress of biochemistry and molecular biology. 16-20 July, 2000. pp. 363. U.K.


PUBLICATIONS
Hung, J.C., Wu, J.L., Li, H.C., Chiu, H.W., Hong, J.R. (2021) The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish. Cells. 10(11):
Hung, J.C., Wu, J.L., Hong, J.R. (2021) Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. International Journal of Molecular Sciences. 22(9):
Shiu, W.L., Huang, K.R., Hung, J.C., Wu, J.L., Hong, J.R. (2016) Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development. Journal of Biomedical Science. 23:31
Su, Y.C., Chiu, H.W., Hung, J.C., Hong, J.R. (2014) Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. Apoptosis : an international journal on programmed cell death. 19(10):1457-70
Huang, H.L., Liu, Y.T., Chen, M.C., Wu, J.L., and Hong, J.R. (2011) Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins. Fish & shellfish immunology. 31(6):970-7
Her, G.M., Hsu, C.C., Hong, J.R., Lai, C.Y., Hsu, M.C., Pang, H.W., Chan, S.K., and Pai, W.Y. (2011) Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio). Biochimica et biophysica acta. Molecular and cell biology of lipids. 1811(9):536-48
Wang, W.L., Liu, W., Gong, H.Y., Hong, J.R., Lin, C.C., and Wu, J.L. (2011) Activation of cytokine expression occurs through the tnfα/nf-κb-mediated pathway in birnavirus-infected cells. Fish & shellfish immunology. 31(1):10-21
Wang, W.L., Hong, J.R., Lin, G.H., Liu, W., Gong, H.Y., Lu, M.W., Lin, C.C., and Wu, J.L. (2011) Stage-Specific Expression of TNFα Regulates Bad/Bid-Mediated Apoptosis and RIP1/ROS-Mediated Secondary Necrosis in Birnavirus-Infected Fish Cells. PLoS One. 6(2):e16740
Chang, C.W., Su, Y.C., Her, G.M., Ken, C.F., and Hong, J.R. (2011) Betanodavirus induces oxidative stress-mediated cell death that prevented by anti-oxidants and zfcatalase in fish cells. PLoS One. 6(10):e25853
Su, Y.C., and Hong, J.R. (2010) Betanodavirus B2 causes ATP depletion-induced cell death via mitochondrial targeting and Complex II inhibition in vitro and in vivo. The Journal of biological chemistry. 285(51):39801-39810
Hsu, C.C., Hou, M.F., Hong, J.R., Wu, J.L., and Her, G.M. (2010) Inducible Male Infertility by Targeted Cell Ablation in Zebrafish Testis. Marine biotechnology (New York, N.Y.). 12(4):466-478
Shieh, Y.S., Chang, Y.S., Hong, J.R., Chen, L.J., Jou, L.K., Hsu, C.C., and Her, G.M. (2010) Increase of hepatic fat accumulation by liver specific expression of Hepatitis B virus X protein in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1801(7):721-730
Chiu, C.L., Wu, J.L., Her, G.M., Chou, Y.L., and Hong, J.R. (2010) Aquatic birnavirus capsid protein, VP3, induces apoptosis via the Bad-mediated mitochondria pathway in fish and mouse cells. Apoptosis : an international journal on programmed cell death. 15(6):653-668
Chen, L.J., Hsu, C.C., Hong, J.R., Jou, L.K., Tseng, H.C., Wu, J.L., Liou, Y.C., and Her, G.M. (2008) Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(4):1070-1081
Wu, H.C., Chiu, C.S., Wu, J.L., Gong, H.Y., Chen, M.C., Lu, M.W., and Hong, J.R. (2008) Zebrafish anti-apoptotic protein zfBcl-x(L) can block betanodavirus protein alpha-induced mitochondria-mediated secondary necrosis cell death. Fish & shellfish immunology. 24(4):436-449
Lu, M.W., Chao, Y.M., Guo, T.C., Santi, N., Evensen, O., Kasani, S.K., Hong, J.R., and Wu, J.L. (2008) The interferon response is involved in nervous necrosis virus acute and persistent infection in zebrafish infection model. Molecular immunology. 45(4):1146-1152
Hong, J.R., Lin, G.H., Lin, C.J., Wang, W.P., Lee, C.C., Lin, T.L., and Wu, J.L. (2004) Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. Development (Cambridge, England). 131(21):5417-5427
Chen, M., Gong, H., Cheng, C., Wang, J., Hong, J., and Wu, J. (2001) Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio. BBA Gene Structure and Expression. 1519(1-2):127-133
Chen, M.C., Gong, H.Y., Cheng, C.Y., Wang, J.P., Hong, J.R., and Wu, J.L. (2000) Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo. Biochemical and Biophysical Research Communications. 279(2):725-731

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