Lab
Chung Bon-chu Lab
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Statement of Research Interest
The establishment of zebrafish model to study brain and sex gland development
We have cloned zebrafish genes which play a role during development. Among them, sox9 is important probably for cartilage development and testis formation. We find the sox9 gene is duplicated in zebrafish. Sox9a and sox9b expression patterns differ, indicating their separate role during development.
Ftz-F1 is a nuclear receptor protein important for segmentation. We find that zebrafish Ftz-F1 gene has two promoters and is alternatively spliced, creating four transcripts. Ftz-F1 is mainly expressed in the somites, spinal cord, mandibula, and gut derivatives, indicating their possible function in these tissues.
Steroidogenic genes, such as CYP11A1, CYP19, and 3-beta-HSD, have also been cloned in our laboratory. They are expressed in the gonads and the brain of zebrafish, two sites important for steroid synthesis. It indicates that steroids may play a role during early development.
We have cloned zebrafish genes which play a role during development. Among them, sox9 is important probably for cartilage development and testis formation. We find the sox9 gene is duplicated in zebrafish. Sox9a and sox9b expression patterns differ, indicating their separate role during development.
Ftz-F1 is a nuclear receptor protein important for segmentation. We find that zebrafish Ftz-F1 gene has two promoters and is alternatively spliced, creating four transcripts. Ftz-F1 is mainly expressed in the somites, spinal cord, mandibula, and gut derivatives, indicating their possible function in these tissues.
Steroidogenic genes, such as CYP11A1, CYP19, and 3-beta-HSD, have also been cloned in our laboratory. They are expressed in the gonads and the brain of zebrafish, two sites important for steroid synthesis. It indicates that steroids may play a role during early development.
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