ZFIN Lab: Higuchi Lab

ZFIN ID: ZDB-LAB-980202-37

Higuchi Lab

PI/Director:	Higuchi, Hiroshi
Co-PI / Senior Researcher:	Muraoka, Osamu
Contact Person:	Higuchi, Hiroshi
Email:	hhiguchi@med.niigata-u.ac.jp
URL:	http://WWW.med.niigata-u.ac.jp/pha/pharm-jp.html
Address:	Department of Pharmacology Niigata University Medical School 1-757 Asahicho-dori Niigata, 951-8510 Japan
Country:	Japan
Phone:	81-25-223-6161 x2270
Fax:	81-25-225-6320
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

gene expression of neural genes and differentiation of neural crest cells

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y.K., Hashimoto, H., and Hibi, M. (2006) Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Nature cell biology. 8(4):329-340

Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.K., Nojima, H., and Hibi, M. (2005) E-cadherin is required for gastrulation cell movements in zebrafish. Mechanisms of Development. 122(6):747-763

Shimizu, T., Bae, Y.K., Muraoka, O., and Hibi, M. (2005) Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Developmental Biology. 279(1):125-141

Bae, Y.K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M. (2004) Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene expression patterns : GEP. 4(4):481-486

Hashimoto, H., Rebagliati, M., Ahmad, N., Muraoka, O., Kurokawa, T., Hibi, M., and Suzuki, T. (2004) The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. Development (Cambridge, England). 131(8):1741-1753

Nojima, H., Shimizu, T., Kim, C.H., Yabe, T., Bae, Y.K., Muraoka, O., Hirata, T., Chitnis, A., Hirano, T., and Hibi, M. (2004) Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. Mechanisms of Development. 121(4):371-386

Yabe, T., Shimizu, T., Muraoka, O., Bae, Y.-K., Hirata, T., Nojima, H., Kawakami, A., Hirano, T., and Hibi, M. (2003) Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Development (Cambridge, England). 130(12):2705-2716

Bae, Y.K., Shimizu, T., Yabe, T., Kim, C.H., Hirata, T., Nojima, H., Muraoka, O., Hirano, T., and Hibi, M. (2003) A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish. Development (Cambridge, England). 130(9):1853-1865

Muraoka, O. (2002) The new technology for controlling gene function in zebrafish. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 120(2):96-100

Muraoka, O., Ichikawa, H., Shi, H., Okumura, S., Taira, E., Higuchi, H., Hirano, T., Hibi, M., and Miki, N. (2000) Kheper, a Novel ZFH/δEF1 Family Member, Regulates the Development of the Neuroectoderm of Zebrafish (Danio rerio). Developmental Biology. 228(1):29-40

Kim, C.H., Ueshima, E., Muraoka, O., Tanaka, H., Yeo, S.Y., Huh, T.L., and Miki, N. (1996) Zebrafish elav/huC homologue as a very early neuronal marker. Neuroscience letters. 216(2):109-112

Kim, C.H., Taira, E., Kuo, C.H., Li, B.S., Okamoto, H., Nakahira, K., Ikenaka, K., Higuchi, H., and Miki, N. (1996) Neuron-specific expression of a chicken gicerin cDNA transient transgenic zebrafish. Neurochemical research. 21:231-237

Kuo, C.H., Uetsuki, T., Kim, C.H., Tanaka, H., Li, B.S., Taira, E., Higuchi, H., Okamoto, H., Yoshikawa, K., and Miki, N. (1995) Determination of a necdin cis-acting element required for neuron specific expression by using zebra fish. Biochemical and Biophysical Research Communications. 211(2):438-446